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Endocrinology, Vol 124, 605-611, Copyright © 1989 by Endocrine Society

ARTICLES

Regulation of blood flow to the rabbit corpus luteum: effects of estradiol and human chorionic gonadotropin

MC Wiltbank, KP Gallagher, RC Dysko and PL Keyes
Department of Physiology, University of Michigan, Ann Arbor 48109-0622.

We tested the hypothesis that estrogen and hCG can modify blood flow in the rabbit corpus luteum. Radioactively labeled microspheres were used to measure luteal blood flow in pseudopregnant rabbits in which estrogen had been withdrawn to initiate premature luteal regression and in pseudopregnant rabbits injected with hCG. Removal of estradiol- filled Silastic capsules on day 10 of pseudopregnancy caused an 80% decrease in the serum progesterone concentration within 24 h. Despite the decline in progesterone secretion, luteal blood flow remained at very high levels and was not different from that in control rabbits treated continuously with estradiol. Replacement of estradiol-filled capsules for 3 h did not change the high rate of blood flow to the corpus luteum, but blood flow in the uterus, vagina, and ovarian stroma was increased. The injection of hCG (10 IU, iv) on day 10 of pseudopregnancy caused a 3-fold increase in blood flow to the nonluteal portion of the ovary and a 3-fold increase in the serum progesterone concentration, but luteal blood flow did not change. We conclude that the acute actions of estradiol or hCG in the rabbit corpus luteum are not mediated by changes in luteal blood flow. Further, the results suggest that the luteal vasculature is regulated differently from the vasculature of other estrogen-responsive tissues and that blood flow in the nonluteal tissues of the ovary can be regulated independently of blood flow in the corpus luteum.


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S.B. Goodman,, K. Kugu,, S.H. Chen,, S. Preutthipan,, K.I. Tilly,, J.L. Tilly,, and A.M. Dharmarajan
Estradiol-Mediated Suppression of Apoptosis in the Rabbit Corpus Luteum Is Associated with a Shift in Expression of bcl-2 Family Members Favoring Cellular Survival
Biol Reprod, October 1, 1998; 59(4): 820 - 827.
[Abstract] [Full Text]


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