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Endocrinology, Vol 124, 701-706, Copyright © 1989 by Endocrine Society

ARTICLES

Insulin promotes growth of the cultured rat osteosarcoma cell line UMR- 106-01: an osteoblast-like cell

J Hickman and A McElduff
Department of Endocrinology, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.

The rat osteogenic sarcoma subclone UMR-106-01 is a cell type with osteoblast-like properties. This cell line has been shown to process specific receptors for insulin and insulin-like growth factor I (IGF- I), but not IGF-II. Insulin at physiological concentrations (1-5 ng/ml) in serum-free medium can maintain cell growth, as assessed by protein accumulation, thymidine uptake, and an increase in cell number. IGF-I is less potent than insulin, but, based on relative binding affinities for the insulin receptor, possibly acts via its own receptor. Insulin also enhances PTH-stimulated cAMP accumulation in these cells both by increasing cell number and an effect independent of cell number. Insulin may have a role in bone homeostasis.


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