Endocrinology, Vol 124, 820-825, Copyright © 1989 by Endocrine Society

ARTICLES

Induction of insulin-like growth factor I messenger ribonucleic acid during regeneration of rat skeletal muscle

D Edwall, M Schalling, E Jennische and G Norstedt
Karolinska Institute, Huddinge University Hospital, Sweden.

Expression of insulin-like growth factor I (IGF-I) was studied in regenerating skeletal muscle. Irreversible damage to muscle cells was induced in the extensor digitorum longus muscle of adult rats by ischemia, preceded by glycogen depletion. IGF-I mRNA levels during the regeneration process were studied for periods up to 10 days after injury using a solution hybridization assay. Increased IGF-I mRNA levels could be demonstrated within 24 h after injury; maximum levels were achieved in 3 days and decreased to approximately normal levels by 10 days. Changes in IGF-I mRNA levels could not be seen in undamaged contralateral extensor digitorum longus muscles during the experimental period. An increase in IGF-I mRNA was also evident in injured muscles of hypophysectomized animals. In situ hybridization at the time of maximum induction showed the presence of IGF-I mRNA in proliferating myoblasts and in satellite cells. IGF-I, thus, may act as a locally produced non-GH dependent trophic factor during regeneration of skeletal muscle after injury.

This article has been cited by other articles:

				W. T. Oliver, J. Rosenberger, R. Lopez, A. Gomez, K. K. Cummings, and M. L. Fiorotto The Local Expression and Abundance of Insulin-Like Growth Factor (IGF) Binding Proteins in Skeletal Muscle Are Regulated by Age and Gender But Not Local IGF-I in Vivo Endocrinology, December 1, 2005; 146(12): 5455 - 5462. [Abstract] [Full Text] [PDF]

				T. Shavlakadze, M. Davies, J. D. White, and M. D. Grounds Early Regeneration of Whole Skeletal Muscle Grafts Is Unaffected by Overexpression of IGF-1 in MLC/mIGF-1 Transgenic Mice J. Histochem. Cytochem., July 1, 2004; 52(7): 873 - 883. [Abstract] [Full Text] [PDF]

				S. B. P. CHARGE and M. A. RUDNICKI Cellular and Molecular Regulation of Muscle Regeneration Physiol Rev, January 1, 2004; 84(1): 209 - 238. [Abstract] [Full Text] [PDF]

				N. F. Paoni, F. Peale, F. Wang, C. Errett-Baroncini, H. Steinmetz, K. Toy, W. Bai, P. M. Williams, S. Bunting, M. E. Gerritsen, et al. Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice Physiol Genomics, December 3, 2002; 11(3): 263 - 272. [Abstract] [Full Text] [PDF]

				M. Carrasco, J. Canicio, M. Palacin, A. Zorzano, and P. Kaliman Identification of Intracellular Signaling Pathways that Induce Myotonic Dystrophy Protein Kinase Expression during Myogenesis Endocrinology, August 1, 2002; 143(8): 3017 - 3025. [Abstract] [Full Text] [PDF]

				O. Halevy, A. Krispin, Y. Leshem, J. P. McMurtry, and S. Yahav Early-age heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R302 - R309. [Abstract] [Full Text] [PDF]

				K. L. Haugk, H.-M. P. Wilson, K. Swisshelm, and L. S. Quinn Insulin-Like Growth Factor (IGF)-Binding Protein-Related Protein-1: An Autocrine/Paracrine Factor That Inhibits Skeletal Myoblast Differentiation but Permits Proliferation in Response to IGF Endocrinology, January 1, 2000; 141(1): 100 - 110. [Abstract] [Full Text] [PDF]

				P. Kaliman, J. Canicio, X. Testar, M. Palacin, and A. Zorzano Insulin-like Growth Factor-II, Phosphatidylinositol 3-Kinase, Nuclear Factor-kappa B and Inducible Nitric-oxide Synthase Define a Common Myogenic Signaling Pathway J. Biol. Chem., June 18, 1999; 274(25): 17437 - 17444. [Abstract] [Full Text] [PDF]

				C. A. Kurtz, T. G. Loebig, D. D. Anderson, P. J. DeMeo, and P. G. Campbell Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model Am. J. Sports Med., May 1, 1999; 27(3): 363 - 369. [Abstract] [Full Text] [PDF]

				H. Yoshimoto, H. Ishihara, A. Ohtsuru, K. Akino, R. Murakami, H. Kuroda, H. Namba, M. Ito, T. Fujii, and S. Yamashita Overexpression of Insulin-Like Growth Factor-1 (IGF-I) Receptor and the Invasiveness of Cultured Keloid Fibroblasts Am. J. Pathol., March 1, 1999; 154(3): 883 - 889. [Abstract] [Full Text] [PDF]

				J. Canicio, E. Gallardo, I. Illa, X. Testar, M. Palacin, A. Zorzano, and P. Kaliman p70 S6 Kinase Activation Is Not Required for Insulin-Like Growth Factor-Induced Differentiation of Rat, Mouse, or Human Skeletal Muscle Cells Endocrinology, December 1, 1998; 139(12): 5042 - 5049. [Abstract] [Full Text] [PDF]

				G. STASSIJNS, G. GAYAN-RAMIREZ, P. DE LEYN, G. VERHOEVEN, P. HERIJGERS, V. de BOCK, R. DOM, R. LYSENS, and M. DECRAMER Systolic Ventricular Dysfunction Causes Selective Diaphragm Atrophy in Rats Am. J. Respir. Crit. Care Med., December 1, 1998; 158(6): 1963 - 1967. [Abstract] [Full Text] [PDF]

				M. D. GROUNDS Age-associated Changes in the Response of Skeletal Muscle Cells to Exercise and Regeneration Ann. N.Y. Acad. Sci., November 20, 1998; 854(1): 78 - 91. [Abstract] [Full Text] [PDF]

				P. Kaliman, J. Canicio, P. R. Shepherd, C. A. Beeton, X. Testar, M. Palacín, and A. Zorzano Insulin-like Growth Factors Require Phosphatidylinositol 3-Kinase to Signal Myogenesis: Dominant Negative p85 Expression Blocks Differentiation of L6E9 Muscle Cells Mol. Endocrinol., January 1, 1998; 12(1): 66 - 77. [Abstract] [Full Text]

				C. E. Perrone, D. Fenwick-Smith, and H. H. Vandenburgh Collagen and Stretch Modulate Autocrine Secretion of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Proteins from Differentiated Skeletal Muscle Cells J. Biol. Chem., February 3, 1995; 270(5): 2099 - 2106. [Abstract] [Full Text] [PDF]

				L Powell-Braxton, P Hollingshead, C Warburton, M Dowd, S Pitts-Meek, D Dalton, N Gillett, and T A Stewart IGF-I is required for normal embryonic growth in mice. Genes & Dev., December 1, 1993; 7(12b): 2609 - 2617. [Abstract] [PDF]