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Endocrinology, Vol 124, 1585-1587, Copyright © 1989 by Endocrine Society

ARTICLES

Diurnal rhythm of melatonin binding in the rat suprachiasmatic nucleus

JT Laitinen, E Castren, O Vakkuri and JM Saavedra
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.

We used quantitative in vitro autoradiography to localize and characterize 2-125I-melatonin binding sites in the rat suprachiasmatic nuclei in relation to pineal melatonin production. In a light:dark cycle of 12:12 h, binding density exhibited significant diurnal variation with a peak at the dark-light transition and a trough 12 hours later. Saturation studies suggested that the decreased binding at light-dark transition might be due to a shift of the putative melatonin receptor to a low affinity state.


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