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Endocrinology, Vol 124, 2013-2015, Copyright © 1989 by Endocrine Society

ARTICLES

Relaxin stimulates prolactin secretion from anterior pituitary cells

MA Sortino, MJ Cronin and PM Wise
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.

The anterior pituitary has recently been implicated as a relaxin target issue because of the cAMP elevation after relaxin treatment. We attempted to correlate this finding with an endocrine response to relaxin in rats. Anterior pituitary cells were enzymatically dispersed and subjected to the reverse hemolytic plaque assay. PRL secretion was significantly stimulated 1.31-fold by human relaxin at the lowest concentration studied (30 pM) and maximally stimulated 1.65-fold at 0.3 nM relaxin. Antibodies directed against relaxin inhibited this effect, as did the PRL inhibitory hormone, dopamine. In contrast to the response of PRL cells, there was no effect or a slight inhibition of LH release after incubation with relaxin. In conclusion, we propose that one of the pituitary cell types responsive to relaxin in culture is the PRL-secreting mammotroph.


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A. J. S. Summerlee, D. J. Hornsby, and D. G. Ramsey
The Dipsogenic Effects of Rat Relaxin: The Effect of Photoperiod and the Potential Role of Relaxin on Drinking in Pregnancy
Endocrinology, May 1, 1998; 139(5): 2322 - 2328.
[Abstract] [Full Text] [PDF]


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