help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Black, V. H.
Right arrow Articles by Martin, K. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Black, V. H.
Right arrow Articles by Martin, K. O.

Endocrinology, Vol 124, 2494-2498, Copyright © 1989 by Endocrine Society

ARTICLES

Effects of age, adrenocorticotropin, and dexamethasone on a male- specific cytochrome P450 localized in the inner zone of the guinea pig adrenal

VH Black, JR Barilla and KO Martin
Department of Cell Biology, New York University School of Medicine, New York 10016.

Guinea pig adrenal microsomes have a capacity for xenobiotic metabolism which is localized to the inner zone, greater in adult males then females, greater in older than in younger males, and suppressed by ACTH. In this paper we show that a cytochrome P450 distinct from P450(21) and P450(17) alpha, which is localized to the inner zone, is male specific, increases with age, and is suppressed by ACTH. This is the first report of a sex-dependent cytochrome P450 in the adrenal. It is immunochemically related to the two members of the P450I family, P450 c and d, neither of which has been reported to be hormonally regulated. The correlation of this cytochrome P450 with the ability of the microsomes to metabolize ethylmorphine suggests that it accounts for this capacity. Whether metabolism of foreign compounds and/or male- specific steroid hydroxylation are its functions in vivo remains to be determined.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
V. H. Black, A. Sanjay, K. van Leyen, B. Lauring, and G. Kreibich
Cholesterol and Steroid Synthesizing Smooth Endoplasmic Reticulum of Adrenocortical Cells Contains High Levels of Proteins Associated with the Translocation Channel
Endocrinology, October 1, 2005; 146(10): 4234 - 4249.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society