Endocrinology, Vol 125, 1060-1066, Copyright © 1989 by Endocrine Society

ARTICLES

Mullerian inhibiting substance in the adult rat ovary during various stages of the estrous cycle

S Ueno, T Kuroda, DT Maclaughlin, RC Ragin, TF Manganaro and PK Donahoe
Pediatric Surgical Research Laboratory, Massachusetts General Hospital, Boston 02114.

Mullerian inhibiting substance (MIS) in the adult rat ovary can be detected by immunohistochemistry in the granulosa cells of growing preantral follicles and in the cumulus oophorus and periluminal granulosa cells of antral follicles in estrus, metestrus, diestrus, and proestrus. Neither the corpus luteum nor atreitic follicles stained for MIS. During proestrus, dramatic changes occurred in the large preovulatory antral follicles, which early in the day manifest intense MIS-specific staining in the granulosa cells located close to the oocyte, however, at 2300 h, just before ovulation when the germinal vesicle was extruded to indicate resumed meiotic division, MIS staining waned. When the morphology of the late preovulatory stage was created experimentally in 26-day-old immature ovaries by stimulating 48 h earlier with hCG, the intense staining of the granulosa cells surrounding the oocytes from untreated ovaries was lost in the cumulus cells of such hCG-treated animals. This temporal pattern of MIS staining and the prior demonstration that MIS could inhibit in vitro meiosis of oocytes from untreated immature rats suggest that this regressor, well characterized in the fetal testis, might function in the ovary as a regulator of oocyte maturation and follicular development during the adult reproductive cycle.

This article has been cited by other articles:

				E. W Kabithe and N. J Place Photoperiod-dependent modulation of anti-Mullerian hormone in female Siberian hamsters, Phodopus sungorus Reproduction, March 1, 2008; 135(3): 335 - 342. [Abstract] [Full Text] [PDF]

				P.A Johnson, T.R Kent, M.E Urick, and J.R Giles Expression and Regulation of Anti-Mullerian Hormone in an Oviparous Species, the Hen Biol Reprod, January 1, 2008; 78(1): 13 - 19. [Abstract] [Full Text] [PDF]

				A. L. Marca and A. Volpe The Anti-Mullerian hormone and ovarian cancer Hum. Reprod. Update, May 1, 2007; 13(3): 265 - 273. [Abstract] [Full Text] [PDF]

				J. A. Visser, A. L. L. Durlinger, I. J. J. Peters, E. R. van den Heuvel, U. M. Rose, P. Kramer, F. H. de Jong, and A. P. N. Themmen Increased Oocyte Degeneration and Follicular Atresia during the Estrous Cycle in Anti-Mullerian Hormone Null Mice Endocrinology, May 1, 2007; 148(5): 2301 - 2308. [Abstract] [Full Text] [PDF]

				G. Meduri, N. Massin, J. Guibourdenche, A. Bachelot, O. Fiori, F. Kuttenn, M. Misrahi, and P. Touraine Serum anti-Mullerian hormone expression in women with premature ovarian failure Hum. Reprod., January 1, 2007; 22(1): 117 - 123. [Abstract] [Full Text] [PDF]

				C. Y. Andersen and A. G. Byskov Estradiol and Regulation of Anti-Mullerian Hormone, Inhibin-A, and Inhibin-B Secretion: Analysis of Small Antral and Preovulatory Human Follicles' Fluid J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4064 - 4069. [Abstract] [Full Text] [PDF]

				D. Modi, D. Bhartiya, and C. Puri Developmental expression and cellular distribution of Mullerian inhibiting substance in the primate ovary. Reproduction, September 1, 2006; 132(3): 443 - 453. [Abstract] [Full Text] [PDF]

				K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws Ovarian follicle development and transgenic mouse models Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555. [Abstract] [Full Text] [PDF]

				M. E. Kevenaar, M. F. Meerasahib, P. Kramer, B. M. N. van de Lang-Born, F. H. de Jong, N. P. Groome, A. P. N. Themmen, and J. A. Visser Serum Anti-Mullerian Hormone Levels Reflect the Size of the Primordial Follicle Pool in Mice Endocrinology, July 1, 2006; 147(7): 3228 - 3234. [Abstract] [Full Text] [PDF]

				D. Goswami and G. S. Conway Premature ovarian failure Hum. Reprod. Update, July 1, 2005; 11(4): 391 - 410. [Abstract] [Full Text] [PDF]

				A. La Marca, S. Malmusi, S. Giulini, L. F. Tamaro, R. Orvieto, P. Levratti, and A. Volpe Anti-Mullerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation Hum. Reprod., December 1, 2004; 19(12): 2738 - 2741. [Abstract] [Full Text] [PDF]

				X. Gueripel, M. Benahmed, and A. Gougeon Sequential Gonadotropin Treatment of Immature Mice Leads to Amplification of Transforming Growth Factor {beta} Action, Via Upregulation of Receptor-Type 1, Smad 2 and 4, and Downregulation of Smad 6 Biol Reprod, March 1, 2004; 70(3): 640 - 648. [Abstract] [Full Text] [PDF]

				C. Weenen, J. S.E. Laven, A. R.M. von Bergh, M. Cranfield, N. P. Groome, J. A. Visser, P. Kramer, B. C.J.M. Fauser, and A. P.N. Themmen Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment Mol. Hum. Reprod., February 1, 2004; 10(2): 77 - 83. [Abstract] [Full Text] [PDF]

				G. Schepers, M. Wilson, D. Wilhelm, and P. Koopman SOX8 Is Expressed during Testis Differentiation in Mice and Synergizes with SF1 to Activate the Amh Promoter in Vitro J. Biol. Chem., July 18, 2003; 278(30): 28101 - 28108. [Abstract] [Full Text] [PDF]

				A. L. L. Durlinger, M. J. G. Gruijters, P. Kramer, B. Karels, H. A. Ingraham, M. W. Nachtigal, J. Th. J. Uilenbroek, J. A. Grootegoed, and A. P. N. Themmen Anti-Mullerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary Endocrinology, March 1, 2002; 143(3): 1076 - 1084. [Abstract] [Full Text] [PDF]

				M. Dutertre, L. Gouedard, F. Xavier, W.-Q. Long, N. di Clemente, J.-Y. Picard, and R. Rey Ovarian Granulosa Cell Tumors Express a Functional Membrane Receptor for Anti-Mullerian Hormone in Transgenic Mice Endocrinology, September 1, 2001; 142(9): 4040 - 4046. [Abstract] [Full Text] [PDF]

				E. A. McGee, R. Smith, N. Spears, M. W. Nachtigal, H. Ingraham, and A. J.W. Hsueh Mullerian Inhibitory Substance Induces Growth of Rat Preantral Ovarian Follicles Biol Reprod, January 1, 2001; 64(1): 293 - 298. [Abstract] [Full Text]

				N. Morikawa, T. R. Clarke, C. D. Novina, K. Watanabe, C. Haqq, M. Weiss, A. L. Roy, and P. K. Donahoe Human Mullerian-Inhibiting Substance Promoter Contains a Functional TFII-I-Binding Initiator Biol Reprod, October 1, 2000; 63(4): 1075 - 1083. [Abstract] [Full Text]

				A. L. L. Durlinger, P. Kramer, B. Karels, F. H. de Jong, J. Th. J. Uilenbroek, J. A. Grootegoed, and A. P. N. Themmen Control of Primordial Follicle Recruitment by Anti-Mullerian Hormone in the Mouse Ovary Endocrinology, December 1, 1999; 140(12): 5789 - 5796. [Abstract] [Full Text]

				E. Rajpert-De Meyts, N. Jorgensen, N. Gram, J. Muller, R. L. Cate, and N. E. Skakkebak Expression of Anti-Mullerian Hormone during Normal and Pathological Gonadal Development: Association with Differentiation of Sertoli and Granulosa Cells J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3836 - 3844. [Abstract] [Full Text] [PDF]

				C. M. HAQQ and P. K. DONAHOE Regulation of Sexual Dimorphism in Mammals Physiol Rev, January 1, 1998; 78(1): 1 - 33. [Abstract] [Full Text] [PDF]

				O Hatano, K Takayama, T Imai, M. Waterman, A Takakusu, T Omura, and K Morohashi Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development Development, January 10, 1994; 120(10): 2787 - 2797. [Abstract] [PDF]