help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mine, T.
Right arrow Articles by Ogata, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mine, T.
Right arrow Articles by Ogata, E.

Endocrinology, Vol 125, 586-591, Copyright © 1989 by Endocrine Society

ARTICLES

Stimulation of glucose production by activin-A in isolated rat hepatocytes

T Mine, I Kojima and E Ogata
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

The effect of activin-A on glycogenolysis was studied in isolated rat hepatocytes. Activin-A stimulated glucose output in hepatocytes in a dose-dependent manner. The maximal effect of the glycogenolytic action of activin-A, which was about 50% of the glucagon action, was obtained at 10(-9) M. When 10(-9) M activin-A and 5 x 10(-9) M glucagon were added simultaneously, the actions of these two agents were additive. In contrast, there was no additivity when 10(-9) M activin-A and 10(-8) M angiotensin-II were added. Activin-A did not increase cAMP at any doses tested, but induced a rapid increase in cytoplasmic free calcium concentration. Activin-A increased the cytoplasmic free calcium concentration even in the presence of 1 microM extracellular calcium, suggesting that activin-A caused calcium release from an intracellular calcium pool(s). The internal calcium pool affected by activin-A appeared to be the same as that affected by either angiotensin-II or vasopressin. When [3H] inositol-labeled hepatocytes were incubated with activin-A, radioactivity in the inositol trisphosphate fraction was rapidly increased. These results indicate that activin-A acts on rat hepatocytes and stimulates glycogenolysis by activating the calcium messenger system.


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
S. La Rosa, S. Uccella, S. Marchet, C. Capella, and R. V. Lloyd
Localization of Inhibins and Activins in Normal Endocrine Cells and Endocrine Tumors of the Gut and Pancreas: an Immunohistochemical and In Situ Hybridization Study
J. Histochem. Cytochem., February 1, 2004; 52(2): 217 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. L. Lau, T. R. Kumar, K. Nishimori, J. Bonadio, and M. M. Matzuk
Activin beta C and beta E Genes Are Not Essential for Mouse Liver Growth, Differentiation, and Regeneration
Mol. Cell. Biol., August 15, 2000; 20(16): 6127 - 6137.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society