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Loss of Androgenic Induction of _2u-Globulin Gene Family in the Liver of NIH Black Rats^*

Departments of Cellular and Structural Biology University of Texas Health Science Center, San Antonio, Texas 78284
Obstetrics and Gynecology University of Texas Health Science Center, San Antonio, Texas 78284
the Biomedical Science Department, General Motors Research Laboratories Warren, Michigan 48090

Address requests for reprints to: Dr. Arun K. Roy, Division of Molecular Genetics, Department of Obstetrics and Gynecology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284.

Abstract

Unlike all known strains of rat, the androgeninducible _2u-globulin gene family is totally silent in the liver of NIH black (NB) rats. No endocrinological or reproductive abnormalities are apparent, and the mRNA for the androgenrepressible hepatic protein SMP-2 is normally regulated in these animals. Furthermore, immunoblot analysis shows a normal level of the male-specific cytoplasmic androgen-binding protein. Cross-breeding of the NB male and Sprague-Dawley female shows that the hybrid male in the F-l generation regains the androgen-dependent expression of _2u-globulin in the liver. These results along with the observation of high constitutive level of _2u-globulin mRNA in the preputial gland of NB rats indicate a tissue- and gene-specific regulatory defect which prevents androgenic induction of _2u-globulin in the liver.

Footnotes

^* This work was supported by NIH Grants AG-03527 and DK-14744.

Received May 5, 1989.

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