help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Udagawa, N.
Right arrow Articles by Suda, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Udagawa, N.
Right arrow Articles by Suda, T.

Endocrinology, Vol 125, 1805-1813, Copyright © 1989 by Endocrine Society

ARTICLES

The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells

N Udagawa, N Takahashi, T Akatsu, T Sasaki, A Yamaguchi, H Kodama, TJ Martin and T Suda
Department of Biochemistry, Showa University, School of Dentistry, Tokyo, Japan.

After our previous report that osteoclast-like multinucleated cells (MNCs) were formed in response to 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] in cocultures of mouse spleen cells and osteoblast- rich populations freshly isolated from fetal mouse calvariae, we examined whether such primary osteoblast-like cells can be replaced by established cell lines in inducing osteoclast-like cell formation. We first used two clonal cell lines simultaneously established from newborn mouse calvariae. One was the osteoblastic cell line MC3T3-E1, and the other was the preadipose cell line MC3T3-G2/PA6. Tartrate- resistant acid phosphatase (TRACP; a marker enzyme of osteoclasts)- positive mononuclear cells and MNCs were formed in the cocultures of spleen cells and MC3T3-G2/PA6 cells in the presence of 1 alpha,25- (OH)2D3. Dexamethasone greatly potentiated TRACP-positive MNC formation induced by 1 alpha,25-(OH)2D3, whereas the glucocorticoid alone had no effect on it. In contrast, osteoblastic MC3T3-E1 cells failed to induce TRACP-positive cells in the cocultures. Another bone marrow-derived stromal cell line ST2 also induced TRACP-positive MNC formation in the cocultures in response to 1 alpha,25-(OH)2D3 and dexamethasone. Salmon calcitonin enhanced cAMP production in the cocultures only when TRACP- positive cells were formed. Autoradiographic studies demonstrated that [125I]calcitonin specifically bound to TRACP-positive cells formed in the cocultures. When spleen cells and either MC3T3-G2/PA6 or ST2 cells were cocultured on sperm whale dentine slices in the presence of 1 alpha,25-(OH)2D3 and dexamethasone, numerous resorption lacunae were formed. These results show that the two bone marrow-derived stromal cell lines can support osteoclast-like cell differentiation in cocultures with spleen cells.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
A. E. Kearns, S. Khosla, and P. J. Kostenuik
Receptor Activator of Nuclear Factor {kappa}B Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
Endocr. Rev., April 1, 2008; 29(2): 155 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. W. Bradley, M. M. Ruan, and M. J. Oursler
Novel Pro-survival Functions of the Kruppel-like Transcription Factor Egr2 in Promotion of Macrophage Colony-stimulating Factor-mediated Osteoclast Survival Downstream of the MEK/ERK Pathway
J. Biol. Chem., March 21, 2008; 283(12): 8055 - 8064.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Horiuchi, T. Miyamoto, H. Takaishi, A. Hakozaki, N. Kosaki, Y. Miyauchi, M. Furukawa, J. Takito, H. Kaneko, K. Matsuzaki, et al.
Cell Surface Colony-Stimulating Factor 1 Can Be Cleaved by TNF-{alpha} Converting Enzyme or Endocytosed in a Clathrin-Dependent Manner
J. Immunol., November 15, 2007; 179(10): 6715 - 6724.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Q. Fu, S. C. Manolagas, and C. A. O'Brien
Parathyroid Hormone Controls Receptor Activator of NF-{kappa}B Ligand Gene Expression via a Distant Transcriptional Enhancer.
Mol. Cell. Biol., September 1, 2006; 26(17): 6453 - 6468.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Swanson, M. Lorentzon, H. H. Conaway, and U. H. Lerner
Glucocorticoid Regulation of Osteoclast Differentiation and Expression of Receptor Activator of Nuclear Factor-{kappa}B (NF-{kappa}B) Ligand, Osteoprotegerin, and Receptor Activator of NF-{kappa}B in Mouse Calvarial Bones
Endocrinology, July 1, 2006; 147(7): 3613 - 3622.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
N. Normanno and W. J Gullick
Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?
Endocr. Relat. Cancer, March 1, 2006; 13(1): 3 - 6.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Gao, H. Deng, H. Zhao, A. Hirbe, J. Harding, L. Ratner, and K. Weilbaecher
HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
Blood, December 15, 2005; 106(13): 4294 - 4302.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
N Normanno, A De Luca, D Aldinucci, M R Maiello, M Mancino, A D'Antonio, R De Filippi, and A Pinto
Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasis
Endocr. Relat. Cancer, June 1, 2005; 12(2): 471 - 482.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
M Nakamura, S Morimoto, Q Yang, T Hisamatsu, N Hanai, Y Nakamura, I Mori, and K Kakudo
Osteoclast-like cells express receptor activity modifying protein 2: application of laser capture microdissection
J. Mol. Endocrinol., February 1, 2005; 34(1): 257 - 261.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. Tolar, S. L. Teitelbaum, and P. J. Orchard
Osteopetrosis
N. Engl. J. Med., December 30, 2004; 351(27): 2839 - 2849.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
M. C. Horowitz, Y. Xi, D. L. Pflugh, D. G. T. Hesslein, D. G. Schatz, J. A. Lorenzo, and A. L. M. Bothwell
Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors
J. Immunol., December 1, 2004; 173(11): 6583 - 6591.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Matsumoto, M. Kogawa, S. Wada, H. Takayanagi, M. Tsujimoto, S. Katayama, K. Hisatake, and Y. Nogi
Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1
J. Biol. Chem., October 29, 2004; 279(44): 45969 - 45979.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Hirotani, N. A. Tuohy, J.-T. Woo, P. H. Stern, and N. A. Clipstone
The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells
J. Biol. Chem., April 2, 2004; 279(14): 13984 - 13992.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Niida, M. Kawahara, Y. Ishizuka, Y. Ikeda, T. Kondo, T. Hibi, Y. Suzuki, K. Ikeda, and N. Taniguchi
{gamma}-Glutamyltranspeptidase Stimulates Receptor Activator of Nuclear Factor-{kappa}B Ligand Expression Independent of Its Enzymatic Activity and Serves as a Pathological Bone-resorbing Factor
J. Biol. Chem., February 13, 2004; 279(7): 5752 - 5756.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ikeda, M. Kasai, J. Suzuki, H. Kuroyama, S. Seki, M. Utsuyama, and K. Hirokawa
Multimerization of the Receptor Activator of Nuclear Factor-{kappa}B Ligand (RANKL) Isoforms and Regulation of Osteoclastogenesis
J. Biol. Chem., November 21, 2003; 278(47): 47217 - 47222.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-I. Hayashi, T. Yamada, M. Tsuneto, T. Yamane, M. Takahashi, L. D. Shultz, and H. Yamazaki
Distinct Osteoclast Precursors in the Bone Marrow and Extramedullary Organs Characterized by Responsiveness to Toll-Like Receptor Ligands and TNF-{alpha}
J. Immunol., November 15, 2003; 171(10): 5130 - 5139.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Takuma, T. Kaneda, T. Sato, S. Ninomiya, M. Kumegawa, and Y. Hakeda
Dexamethasone Enhances Osteoclast Formation Synergistically with Transforming Growth Factor-{beta} by Stimulating the Priming of Osteoclast Progenitors for Differentiation into Osteoclasts
J. Biol. Chem., November 7, 2003; 278(45): 44667 - 44674.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-K. Lee, J. F. Kalinowski, S. L. Jastrzebski, L. Puddington, and J. A. Lorenzo
Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis
Endocrinology, August 1, 2003; 144(8): 3524 - 3531.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Liu, Z. Shi, A. Silveira, J. Liu, M. Sawadogo, H. Yang, and X. Feng
Involvement of Upstream Stimulatory Factors 1 and 2 in RANKL-induced Transcription of Tartrate-resistant Acid Phosphatase Gene during Osteoclast Differentiation
J. Biol. Chem., May 30, 2003; 278(23): 20603 - 20611.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
C. Miyaura, M. Inada, C. Matsumoto, T. Ohshiba, N. Uozumi, T. Shimizu, and A. Ito
An Essential Role of Cytosolic Phospholipase A2{alpha} in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation
J. Exp. Med., May 19, 2003; 197(10): 1303 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Yamada, H. Yamazaki, T. Yamane, M. Yoshino, H. Okuyama, M. Tsuneto, T. Kurino, S.-I. Hayashi, and S. Sakano
Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells
Blood, March 15, 2003; 101(6): 2227 - 2234.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-K. Lee, J. Kalinowski, S. Jastrzebski, and J. A. Lorenzo
1,25 (OH)2 Vitamin D3-Stimulated Osteoclast Formation in Spleen-Osteoblast Cocultures Is Mediated in Part by Enhanced IL-1{alpha} and Receptor Activator of NF-{kappa}B Ligand Production in Osteoblasts
J. Immunol., September 1, 2002; 169(5): 2374 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Ragab, J. L. Nalepka, Y. Bi, and E. M. Greenfield
Cytokines synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells
Am J Physiol Cell Physiol, September 1, 2002; 283(3): C679 - C687.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. Nakamura, T. Tsuji, A. Hirata, and T. Yamamoto
Localization of Osteoprotegerin (OPG) on Bone Surfaces and Cement Lines in Rat Tibia
J. Histochem. Cytochem., July 1, 2002; 50(7): 945 - 954.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. D. Roodman
Biology of Osteoclast Activation in Cancer
J. Clin. Oncol., August 1, 2001; 19(15): 3562 - 3571.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yamagishi, E. Otsuka, and H. Hagiwara
Reciprocal Control of Expression of mRNAs for Osteoclast Differentiation Factor and OPG in Osteogenic Stromal Cells by Genistein: Evidence for the Involvement of Topoisomerase II in Osteoclastogenesis
Endocrinology, August 1, 2001; 142(8): 3632 - 3637.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yamane, T. Kunisada, H. Tsukamoto, H. Yamazaki, H. Niwa, S. Takada, and S.-I. Hayashi
Wnt Signaling Regulates Hemopoiesis Through Stromal Cells
J. Immunol., July 15, 2001; 167(2): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. J. Horwood, J. Elliott, T. J. Martin, and M. T. Gillespie
IL-12 Alone and in Synergy with IL-18 Inhibits Osteoclast Formation In Vitro
J. Immunol., April 15, 2001; 166(8): 4915 - 4921.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Ikeda, M. Kasai, M. Utsuyama, and K. Hirokawa
Determination of Three Isoforms of the Receptor Activator of Nuclear Factor-{{kappa}}B Ligand and Their Differential Expression in Bone and Thymus
Endocrinology, April 1, 2001; 142(4): 1419 - 1426.
[Abstract] [Full Text]

Home page
 JBJSHome page
Y. Bi, R. R. VanDeMotter, A. A. Ragab, V. M. Goldberg, J. M. Anderson, and E. M. Greenfield
Titanium Particles Stimulate Bone Resorption by Inducing Differentiation of Murine Osteoclasts
J. Bone Joint Surg. Am., April 1, 2001; 83(4): 501 - 501.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. Takami, N. Takahashi, N. Udagawa, C. Miyaura, K. Suda, J.-T. Woo, T. J. Martin, K. Nagai, and T. Suda
Intracellular Calcium and Protein Kinase C Mediate Expression of Receptor Activator of Nuclear Factor-{{kappa}}B Ligand and Osteoprotegerin in Osteoblasts
Endocrinology, December 1, 2000; 141(12): 4711 - 4719.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Udagawa, N. Takahashi, H. Yasuda, A. Mizuno, K. Itoh, Y. Ueno, T. Shinki, M. T. Gillespie, T. J. Martin, K. Higashio, et al.
Osteoprotegerin Produced by Osteoblasts Is an Important Regulator in Osteoclast Development and Function
Endocrinology, September 1, 2000; 141(9): 3478 - 3484.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Yamaguchi, T. Komori, and T. Suda
Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1
Endocr. Rev., August 1, 2000; 21(4): 393 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. C. Manolagas
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Endocr. Rev., April 1, 2000; 21(2): 115 - 137.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
L. Huang, J. Xu, D. J. Wood, and M. H. Zheng
Gene Expression of Osteoprotegerin Ligand, Osteoprotegerin, and Receptor Activator of NF-{kappa}B in Giant Cell Tumor of Bone : Possible Involvement in Tumor Cell-Induced Osteoclast-Like Cell Formation
Am. J. Pathol., March 1, 2000; 156(3): 761 - 767.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Arai, T. Miyamoto, O. Ohneda, T. Inada, T. Sudo, K. Brasel, T. Miyata, D. M. Anderson, and T. Suda
Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of c-Fms and Receptor Activator of Nuclear Factor {kappa}B (RANK) Receptors
J. Exp. Med., December 20, 1999; 190(12): 1741 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. J. Thomas, T. A. Guise, J. J. Yin, J. Elliott, N. J. Horwood, T. J. Martin, and M. T. Gillespie
Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation
Endocrinology, October 1, 1999; 140(10): 4451 - 4458.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
G. Mbalaviele, N. Jaiswal, A. Meng, L. Cheng, C. Van Den Bos, and M. Thiede
Human Mesenchymal Stem Cells Promote Human Osteoclast Differentiation from CD34+ Bone Marrow Hematopoietic Progenitors
Endocrinology, August 1, 1999; 140(8): 3736 - 3743.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. A. Hentunen, S. H. Jackson, H. Chung, S. V. Reddy, J. Lorenzo, S. J. Choi, and G. D. Roodman
Characterization of Immortalized Osteoclast Precursors Developed from Mice Transgenic for Both bcl-XL and Simian Virus 40 Large T Antigen
Endocrinology, July 1, 1999; 140(7): 2954 - 2961.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. Otsuka, A. Yamaguchi, S. Hirose, and H. Hagiwara
Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid
Am J Physiol Cell Physiol, July 1, 1999; 277(1): C132 - C138.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. T. Gillespie, and T. J. Martin
Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families
Endocr. Rev., June 1, 1999; 20(3): 345 - 357.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Pederson, M. Kremer, J. Judd, D. Pascoe, T. C. Spelsberg, B. L. Riggs, and M. J. Oursler
Androgens regulate bone resorption activity of isolated osteoclasts in vitro
PNAS, January 19, 1999; 96(2): 505 - 510.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Abu-Amer, F. P. Ross, K. P. McHugh, A. Livolsi, J.-F. Peyron, and S. L. Teitelbaum
Tumor Necrosis Factor-alpha Activation of Nuclear Transcription Factor-kappa B in Marrow Macrophages Is Mediated by c-Src Tyrosine Phosphorylation of Ikappa Balpha
J. Biol. Chem., November 6, 1998; 273(45): 29417 - 29423.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Takai, M. Kanematsu, K. Yano, E. Tsuda, K. Higashio, K. Ikeda, K. Watanabe, and Y. Yamada
Transforming Growth Factor-beta Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells
J. Biol. Chem., October 16, 1998; 273(42): 27091 - 27096.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. Lecanda, D. A. Towler, K. Ziambaras, S.-L. Cheng, M. Koval, T. H. Steinberg, and R. Civitelli
Gap Junctional Communication Modulates Gene Expression in Osteoblastic Cells
Mol. Biol. Cell, August 1, 1998; 9(8): 2249 - 2258.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
K. A. Kelly, S. Tanaka, R. Baron, and J. M. Gimble
Murine Bone Marrow Stromally Derived BMS2 Adipocytes Support Differentiation and Function of Osteoclast-Like Cells in Vitro
Endocrinology, April 1, 1998; 139(4): 2092 - 2101.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Yasuda, N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S.-i. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, et al.
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
PNAS, March 31, 1998; 95(7): 3597 - 3602.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Rubin, D. M. Biskobing, L. Jadhav, D. Fan, M. S. Nanes, S. Perkins, and X. Fan
Dexamethasone Promotes Expression of Membrane-Bound Macrophage Colony-Stimulating Factor in Murine Osteoblast-Like Cells
Endocrinology, March 1, 1998; 139(3): 1006 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Yasuda, N. Shima, N. Nakagawa, S.-I. Mochizuki, K. Yano, N. Fujise, Y. Sato, M. Goto, K. Yamaguchi, M. Kuriyama, et al.
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro
Endocrinology, March 1, 1998; 139(3): 1329 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Muguruma and M. Y. Lee
Isolation and Characterization of Murine Clonogenic Osteoclast Progenitors by Cell Surface Phenotype Analysis
Blood, February 15, 1998; 91(4): 1272 - 1279.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Yamane, T. Kunisada, H. Yamazaki, T. Era, T. Nakano, and S.-I. Hayashi
Development of Osteoclasts From Embryonic Stem Cells Through a Pathway That Is c-fms but not c-kit Dependent
Blood, November 1, 1997; 90(9): 3516 - 3523.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N. Udagawa, N. J. Horwood, J. Elliott, A. Mackay, J. Owens, H. Okamura, M. Kurimoto, T. J. Chambers, T.  J. Martin, and M. T. Gillespie
Interleukin-18 (Interferon-gamma -inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-gamma to Inhibit Osteoclast Formation
J. Exp. Med., March 17, 1997; 185(6): 1005 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Jimi, T. Ikebe, N. Takahashi, M. Hirata, T. Suda, and T. Koga
Interleukin-1alpha Activates an NF-kappaB-like Factor in Osteoclast-like Cells
J. Biol. Chem., March 1, 1996; 271(9): 4605 - 4608.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Matsumoto, T. Sudo, T. Saito, H. Osada, and M. Tsujimoto
Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-kappa B Ligand (RANKL)
J. Biol. Chem., September 29, 2000; 275(40): 31155 - 31161.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Abu-Amer, J. Erdmann, L. Alexopoulou, G. Kollias, F. P. Ross, and S. L. Teitelbaum
Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis
J. Biol. Chem., August 25, 2000; 275(35): 27307 - 27310.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society