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Endocrinology, Vol 125, 2224-2226, Copyright © 1989 by Endocrine Society

ARTICLES

Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors

JW Funder, PT Pearce, R Smith and J Campbell
Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia.

In vitro, Type I receptors have high and equivalent affinity for aldosterone, corticosterone and cortisol: in vivo, physiological mineralocorticoid target tissues (kidney, colon, parotid) are highly aldosterone-selective, in contrast with hippocampus and heart. In the present study we show that the mesenteric vascular arcade is similarly highly aldosterone-selective in vivo, and in vitro shows considerable levels of 11 beta OH steroid dehydrogenase activity, previously postulated as the mechanism whereby glucocorticoids are excluded from physiological mineralocorticoid receptors.


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