help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Urbanski, H. F.
Right arrow Articles by Ojeda, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Urbanski, H. F.
Right arrow Articles by Ojeda, S. R.

Endocrinology, Vol 126, 1774-1776, Copyright © 1990 by Endocrine Society

ARTICLES

A role for N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty

HF Urbanski and SR Ojeda
Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006.

The physiological role of N-methyl-D-aspartate (NMDA) receptors in controlling LH secretion and the initiation of puberty was investigated using two specific antagonists, MK-801 and DL-2-amino-5-phosphono valeric acid (AP-5). Single daily sc injections of MK-801 (0.1-0.2 mg/kg BW), a noncompetitive NMDA receptor antagonist, given to prepubertal rats significantly delayed but did not prevent the timing of puberty, as determined by the age at vaginal opening and first ovulation. Infusion of MK-801 (5 micrograms/h) via osmotic minipumps for 4 days inhibited the postovariectomy rise of LH secretion in prepubertal rats. Both MK-801 (0.2 mg/kg BW, sc) and AP-5 (4 x 30 mg, iv), a competitive NMDA receptor antagonist, blocked the estradiol- induced LH surge in prepubertal ovariectomized rats. These results demonstrate that blockade of NMDA receptors can prevent the development of enhanced LH secretion in female rats undergoing sexual maturation. Moreover, they support the view that activation of NMDA receptors significantly contributes to the physiological initiation of the pubertal process.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
J. Clasadonte, P. Poulain, J.-C. Beauvillain, and V. Prevot
Activation of Neuronal Nitric Oxide Release Inhibits Spontaneous Firing in Adult Gonadotropin-Releasing Hormone Neurons: A Possible Local Synchronizing Signal
Endocrinology, February 1, 2008; 149(2): 587 - 596.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. d'Anglemont de Tassigny, C. Campagne, B. Dehouck, D. Leroy, G. R. Holstein, J.-C. Beauvillain, V. Buee-Scherrer, and V. Prevot
Coupling of Neuronal Nitric Oxide Synthase to NMDA Receptors via Postsynaptic Density-95 Depends on Estrogen and Contributes to the Central Control of Adult Female Reproduction
J. Neurosci., June 6, 2007; 27(23): 6103 - 6114.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
W. Yin, J. M. Mendenhall, S. B. Bratton, T. Oung, W. G. M. Janssen, J. H. Morrison, and A. C. Gore
Novel Localization of NMDA Receptors Within Neuroendocrine Gonadotropin-Releasing Hormone Terminals
Experimental Biology and Medicine, May 1, 2007; 232(5): 662 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. M. Windsor-Engnell, E. Kasuya, M. Mizuno, K. L. Keen, and E. Terasawa
An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)
Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1000 - E1009.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Lee, J. K. Hiney, M. D. Pine, V. K. Srivastava, and W. L. Dees
Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action
J. Physiol., February 1, 2007; 578(3): 765 - 772.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. C. Cottrell, R. E. Campbell, S.-K. Han, and A. E. Herbison
Postnatal Remodeling of Dendritic Structure and Spine Density in Gonadotropin-Releasing Hormone Neurons
Endocrinology, August 1, 2006; 147(8): 3652 - 3661.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. El-Etr, Y. Akwa, E.-E. Baulieu, and M. Schumacher
The Neuroactive Steroid Pregnenolone Sulfate Stimulates the Release of Gonadotropin-Releasing Hormone from GT1-7 Hypothalamic Neurons, through N-Methyl-D-Aspartate Receptors
Endocrinology, June 1, 2006; 147(6): 2737 - 2743.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. R. Ojeda, A. Lomniczi, C. Mastronardi, S. Heger, C. Roth, A.-S. Parent, V. Matagne, and A. E. Mungenast
Minireview: The Neuroendocrine Regulation of Puberty: Is the Time Ripe for a Systems Biology Approach?
Endocrinology, March 1, 2006; 147(3): 1166 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Lomniczi, A. Cornea, M. E. Costa, and S. R. Ojeda
Hypothalamic Tumor Necrosis Factor-{alpha} Converting Enzyme Mediates Excitatory Amino Acid-Dependent Neuron-to-Glia Signaling in the Neuroendocrine Brain
J. Neurosci., January 4, 2006; 26(1): 51 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. R. Shimshek, T. Bus, V. Grinevich, F. N. Single, V. Mack, R. Sprengel, D. J. Spergel, and P. H. Seeburg
Impaired Reproductive Behavior by Lack of GluR-B Containing AMPA Receptors But Not of NMDA Receptors in Hypothalamic and Septal Neurons
Mol. Endocrinol., January 1, 2006; 20(1): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. Pine, B. Lee, R. Dearth, J. K. Hiney, and W. L. Dees
Manganese Acts Centrally to Stimulate Luteinizing Hormone Secretion: A Potential Influence on Female Pubertal Development
Toxicol. Sci., June 1, 2005; 85(2): 880 - 885.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Matagne, M.-C. Lebrethon, A. Gerard, and J.-P. Bourguignon
Kainate/Estrogen Receptor Involvement in Rapid Estradiol Effects in Vitro and Intracellular Signaling Pathways
Endocrinology, May 1, 2005; 146(5): 2313 - 2323.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. A. Dissen, R. K. Dearth, H. M. Scott, S. R. Ojeda, and W. L. Dees
Alcohol Alters Luteinizing Hormone Secretion in Immature Female Rhesus Monkeys by a Hypothalamic Action
Endocrinology, October 1, 2004; 145(10): 4558 - 4564.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Matagne, G. Rasier, M.-C. Lebrethon, A. Gerard, and J.-P. Bourguignon
Estradiol Stimulation of Pulsatile Gonadotropin-Releasing Hormone Secretion in Vitro: Correlation with Perinatal Exposure to Sex Steroids and Induction of Sexual Precocity in Vivo
Endocrinology, June 1, 2004; 145(6): 2775 - 2783.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Bouret, S. De Seranno, J.-C. Beauvillain, and V. Prevot
Transforming Growth Factor {beta}1 May Directly Influence Gonadotropin-Releasing Hormone Gene Expression in the Rat Hypothalamus
Endocrinology, April 1, 2004; 145(4): 1794 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Chakraborty, L. Ng, and A. C. Gore
Age-Related Changes in Estrogen Receptor {beta} in Rat Hypothalamus: A Quantitative Analysis
Endocrinology, September 1, 2003; 144(9): 4164 - 4171.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Dziedzic, V. Prevot, A. Lomniczi, H. Jung, A. Cornea, and S. R. Ojeda
Neuron-to-Glia Signaling Mediated by Excitatory Amino Acid Receptors Regulates ErbB Receptor Function in Astroglial Cells of the Neuroendocrine Brain
J. Neurosci., February 1, 2003; 23(3): 915 - 926.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Chakraborty, L. Ng, and A. C. Gore
Colocalization and Hormone Regulation of Estrogen Receptor {alpha} and N-Methyl-D-Aspartate Receptor in the Hypothalamus of Female Rats
Endocrinology, January 1, 2003; 144(1): 299 - 305.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. N. Ottem, J. G. Godwin, and S. L. Petersen
Glutamatergic Signaling through the N-Methyl-D-Aspartate Receptor Directly Activates Medial Subpopulations of Luteinizing Hormone-Releasing Hormone (LHRH) Neurons, But Does Not Appear to Mediate the Effects of Estradiol on LHRH Gene Expression
Endocrinology, December 1, 2002; 143(12): 4837 - 4845.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Bilger, S. Heger, D. W. Brann, A. Paredes, and S. R. Ojeda
A Conditional Tetracycline-Regulated Increase in Gamma Amino Butyric Acid Production near Luteinizing Hormone-Releasing Hormone Nerve Terminals Disrupts Estrous Cyclicity in the Rat
Endocrinology, May 1, 2001; 142(5): 2102 - 2114.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
E. Terasawa and D. L. Fernandez
Neurobiological Mechanisms of the Onset of Puberty in Primates
Endocr. Rev., February 1, 2001; 22(1): 111 - 151.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
A. C. Gore, G. Yeung, J. H. Morrison, and T. Oung
Neuroendocrine Aging in the Female Rat: The Changing Relationship of Hypothalamic Gonadotropin-Releasing Hormone Neurons and N-Methyl-D-Aspartate Receptors
Endocrinology, December 1, 2000; 141(12): 4757 - 4767.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. J. Suter, C. R. Pohl, and M. E. Wilson
Circulating Concentrations of Nocturnal Leptin, Growth Hormone, and Insulin-Like Growth Factor-I Increase before the Onset of Puberty in Agonadal Male Monkeys: Potential Signals for the Initiation of Puberty
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 808 - 814.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
L. E. Claypool, E. Kasuya, Y. Saitoh, F. Marzban, and E. Terasawa
N-Methyl D,L-Aspartate Induces the Release of Luteinizing Hormone-Releasing Hormone in the Prepubertal and Pubertal Female Rhesus Monkey as Measured by in Vivo Push-Pull Perfusion in the Stalk-Median Eminence
Endocrinology, January 1, 2000; 141(1): 219 - 228.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. M. Adams, R. A. Flagg, and A. C. Gore
Perinatal Changes in Hypothalamic N-Methyl-D-Aspartate Receptors and Their Relationship to Gonadotropin-Releasing Hormone Neurons
Endocrinology, May 1, 1999; 140(5): 2288 - 2296.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
G. Gu, F. Varoqueaux, and R. B. Simerly
Hormonal Regulation of Glutamate Receptor Gene Expression in the Anteroventral Periventricular Nucleus of the Hypothalamus
J. Neurosci., April 15, 1999; 19(8): 3213 - 3222.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Kasuya, C. L. Nyberg, K. Mogi, and E. Terasawa
A Role of {gamma}-Amino Butyric Acid (GABA) and Glutamate in Control of Puberty in Female Rhesus Monkeys: Effect of an Antisense Oligodeoxynucleotide for GAD67 Messenger Ribonucleic Acid and MK801 on Luteinizing Hormone-Releasing Hormone Release
Endocrinology, February 1, 1999; 140(2): 705 - 712.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
D. W. Brann and V. B. Mahesh
Excitatory Amino Acids: Evidence for a Role in the Control of Reproduction and Anterior Pituitary Hormone Secretion
Endocr. Rev., October 1, 1997; 18(5): 678 - 700.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
A. C. Gore, T. J. Wu, J. J. Rosenberg, and J. L. Roberts
Gonadotropin-Releasing Hormone and NMDA Receptor Gene Expression and Colocalization Change during Puberty in Female Rats
J. Neurosci., September 1, 1996; 16(17): 5281 - 5289.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society