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Endocrinology, Vol 126, 2228-2230, Copyright © 1990 by Endocrine Society

ARTICLES

Evidence for the regulation of 3 beta-hydroxysteroid dehydrogenase messenger RNA by human chorionic gonadotrophin in luteinized porcine granulosa cells

PJ Chedrese, VL The, F Labrie, AV Juorio and BD Murphy
Reproductive Biology Research Unit, Univ. Saskatchewan, Saskatoon, Canada.

The effects of hCG on the abundance of messenger RNA for the steroidogenic enzyme 3 beta-hydroxysteroid dehydrogenase (3 beta-OHSD) were studied in luteinized porcine granulosa cells. There were dose- dependent increases in the mRNA for this enzyme after 8 h incubation with hCG or dibutyryl cAMP. The results suggest that LH-like hormones regulate the expression of the 3 beta-OHSD gene in luteinized tissue, and this genomic regulation is a component of the luteotrophic regulation of steroidogenesis in the ovary.


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W. C. Duncan, G. M. Cowen, and P. J. Illingworth
Steroidogenic enzyme expression in human corpora lutea in the presence and absence of exogenous human chorionic gonadotrophin (HCG)
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[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
T. M. Penning
Molecular Endocrinology of Hydroxysteroid Dehydrogenases
Endocr. Rev., June 1, 1997; 18(3): 281 - 305.
[Abstract] [Full Text]


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