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Strain Differences in the Ontogeny of Estrogen Receptors in Murine Uterine Epithelium^*

ROBERT M. BIGSBY, LI AIXIN, KENNETH LUO and GERALD R. CUNHA

the Department of Anatomy, University of California (K.L., G.R.C.) San Francisco, California 94143
Departments of Obstetrics and Gynecology (R.M.B., L.A.) and Physiology and Biophysics (R.M.B.), Indiana University School of Medicine Indianapolis, Indiana 46202–5196

Address all correspondence and requests for reprints to: Dr. Robert M. Bigsby, Department of Obstetrics and Gynecology, MF110, 1001 Walnut Street, Indianapolis, Indiana 46202-5196.

Abstract

The expression of estrogen receptor (ER) in the reproductive tracts of neonatal mice was examined using immunocytochemical and autoradiographic methods. Two strains of mice used in previous studies that reported contradictory results showed different rates of uterine epithelial development. In the inbred strain, BALB/c, the epithelium was devoid of receptor from birth through 5 days of age, while uterine epithelial cells of the outbred strain, CD-I, expressed ER as early as 3 days of age. Oviductal epithelium and cervical epithelium expressed ER on the day of birth in CD-I mice. Glandular ontogeny in the uteri of CD-I animals was also advanced by 3 days compared to that of BALB/c mice. These observations reconcile the conflicting reports of ER ontogeny in the neonatal mouse. More importantly, these results confirm our earlier observations, indicating that the cells lining uteri of 2- and 4-day-old BALB/c mice lack ER at a time when estrogen induces their proliferation. (Endocrinology 126: 2592–2596, 1990)

Footnotes

^* This work was supported by NIH Grants HD-23244 (to R.M.B.), HD-17491 (to G.R.C.), and CA-05388 (to G.R.C.). Presented in part at the 69th Annual Meeting of The Endocrine Society, Indianapolis, IN, 1987.

Present address: Center for Agricultural Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Received December 21, 1989.

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