Endocrinology, Vol 126, 3053-3058, Copyright © 1990 by Endocrine Society

ARTICLES

Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide [published erratum appears in Endocrinology 1990 Aug;127(2):657]

JI Koenig, K Snow, BD Clark, R Toni, JG Cannon, AR Shaw, CA Dinarello, S Reichlin, SL Lee and RM Lechan
Department of Medicine, New England Medical Center Hospital, Boston, Massachusetts 02111.

Using a specific antiserum recognizing recombinant rat interleukin-1 beta (IL-1 beta), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Authenticity was established by Northern blot hybridization using a specific rat IL-1 beta cRNA probe, revealing a 1.8-kilobase mRNA identical to that in the spleen. The marked increase in anterior pituitary IL-1 beta message after the administration of bacterial lipopolysaccharide, raises the possibility that IL-1 beta may be involved in paracrine or autocrine regulation of pituitary function during infectious challenge.

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