This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by ELFORD, P. R. Articles by LAMBERTS, S. W. J. Search for Related Content PubMed PubMed Citation Articles by ELFORD, P. R. Articles by LAMBERTS, S. W. J.

Contrasting Modulation by Transforming Growth Factor-β-1 of Insulin-Like Growth Factor-I Production in Osteoblasts and Chondrocytes

Sandoz Research Institute Berne Ltd., CH-3001 Berne, Switzerland; and the Department of Internal Medicine, Erasmus University (S. W.J.L.) NL-3015 GD Rotterdam, The Netherlands

Address requests for reprints to: Dr. Peter R. Elford, Sandoz Research Institute Berne Ltd., P.O. Box CH-3001, Berne, Switzerland.

Abstract

The importance of locally produced insulin-like growth factor-I (IGF-I) in connective tissues has recently been recognized. It has been postulated that the action of anabolic hormones on bone may be mediated through local IGF-I release. However, whether IGF-I can also be modulated by other locally acting cytokines has not been addressed. Transforming growth factor-β (TGFβ) is a polypeptide thought to be involved in the regulation of tissue growth and repair. Although the occurrence of TGFβ is ubiquitous, particularly high amounts are found in bone and cartilage. In this study the effect of TGFβ-1 on immunoreactive IGF-I production by osteoblasts and chondrocytes was investigated and compared to that of PTH on osteoblasts or basic fibroblast growth factor (bFGF) on chondrocytes. Both TGFβ-1 and PTH stimulated IGF-I release from osteoblasts, which was further enhanced when both were consecutively present. Contrastingly, although bFGF stimulated IGF-I release by chondrocytes, TGFβ-1 was inhibitory and also blunted the effect of bFGF when both were present concurrently. These findings demonstrate that the regulation of local IGF-I production in bone and cartilage may differ and illustrate the complex nature of local cytokine interactions. (Endocrinology 127: 1635–1639, 1990)

Received March 29, 1990.

This article has been cited by other articles:

				S. Shi, S. Mercer, G. J. Eckert, and S. B. Trippel Growth Factor Regulation of Growth Factors in Articular Chondrocytes J. Biol. Chem., March 13, 2009; 284(11): 6697 - 6704. [Abstract] [Full Text] [PDF]

				K. Janssens, P. ten Dijke, S. Janssens, and W. Van Hul Transforming Growth Factor-{beta}1 to the Bone Endocr. Rev., October 1, 2005; 26(6): 743 - 774. [Abstract] [Full Text] [PDF]

				D. Frenz, W Liu, J. Williams, V Hatcher, V Galinovic-Schwartz, K. Flanders, and T. Van de Water Induction of chondrogenesis: requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor-beta Development, January 2, 1994; 120(2): 415 - 424. [Abstract] [PDF]