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Expression of Rat Prolactin-Like Protein B in Deciduoma of Pseudopregnant Rat and in Decidua During Early Pregnancy^*

F. CROZE, T. G. KENNEDY, I. C. SCHROEDTER and H. G. FRIESEN

Department of Physiology, (F.C., I.C.S., H.G.F.) Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0W3; and Departments of Obstetrics & Gynecology and Physiology (T.G.K.), The University of Western Ontario London, Ontario, Canada, N6A 5A5

Address reprint requests to: Dr. H. G. Friesen, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0W3.

Abstract

The rat PRL-like protein-B (rPLP-B) complementary DNA (cDNA), originally cloned from a late term placental library, hybridizes to transcripts in the deciduoma tissue artificially produced in pseudopregnant rats. The expression of rPLP-B in deciduoma is first observed 48 h (pseudopregnancy day 7) after the deciduogenic stimulus and increases to a maximum by 96-120 h (pseudopregnancy day 9-10). In situ hybridization studies show that rPLP-B hybridizes specifically to the antimesometrial cells of deciduoma tissue in day 9 pseudopregnant rats and to the homologous cells of the decidua that surround the embryo-trophoblastic structure at day 9 of pregnancy. A temporal study on the expression of rPLP-B during pregnancy shows that rPLP-B is concomitantly expressed by the decidual cells of maternal origin and the cytotrophoblast of fetal origin around day 13 of pregnancy. (Endocrinology 127: 2665–2672, 1990)

Footnotes

^* This work was supported by the Medical Research Council of Canada Grant MA-10414 (to T.G.K.) and MRC-MT 1825 (to H.G.F.), and USPHS Grant HD-07843-15 (to H.G.F.)

Present address: Canadian Red Cross Society. National Reference Laboratory, Protein Chemistry, 1800 Alta Vista Drive, Ottawa, Canada, K1G 4J5.

Received May 14, 1990.

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