This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MATSUKAWA, S. Articles by REID, I. A. Search for Related Content PubMed PubMed Citation Articles by MATSUKAWA, S. Articles by REID, I. A.

Role of Endogenous Angiotensin II in the Control of Vasopressin Secretion during Hypovolemia and Hypotension in Conscious Rabbits^*

Department of Physiology, University of California San Francisco, California 94143
Ames Research Center Moffett Field, California 94035

Address all correspondence and requests for reprints to: Dr. Ian A. Reid, Department of Physiology, Box 0444, University of California, San Francisco, California 94143-0444.

Abstract

In order to investigate the physiological role of angiotensin II (ANG II) in the control of vasopressin (VP) secretion, the VP responses to hypotension induced by hemorrhage (20 ml/kg, n = 10) or nitroprusside infusion (1–10 Mg/kgmin, n = 9) were studied with or without blockade of ANG II formation by the converting enzyme inhibitor captopril in conscious rabbits. Administration of captopril (5 mg/kg, iv) caused a small decrease in mean arterial pressure but did not enhance the hypotensive response to subsequent hemorrhage or nitroprusside infusion. The renin response to both stimuli was enhanced by captopril, whereas the increase in plasma ANG II concentration was attenuated. Plasma VP (PAVP) concentration increased during hemorrhage (2.0 ± 0.2-113.6 ± 47.7 pg/ ml, P < 0.01) and nitroprusside infusion (2.1 ± 0.3-5.1 ± 1.0 pg/ ml, P < 0.01). Captopril did not change basal plasma PAVP, nor did it attenuate the VP responses to hemorrhage or nitroprusside. Indeed, captopril tended to enhance the VP responses to hemorrhage (2.3 ± 0.3-147.1 ± 65.9 pg/ml) and nitroprusside infusion (1.9 ± 0.2-15.4 ± 6.0 pg/ml). The relationship between log PAVP and mean arterial pressure during hemorrhage and nitroprusside infusion in the presence of captopril was not different than in the absence of captopril. These results indicate that in conscious rabbits, the renin-angiotensin system does not contribute to the increase in VP secretion during hypotension induced by hemorrhage or nitroprusside infusion. (Endocrinology 128: 204–210, 1991)

Footnotes

^* This research was supported by NIH Grant HL-29714.

Received July 9, 1990.

This article has been cited by other articles:

				M. C. Zimmerman, R. V. Sharma, and R. L. Davisson Superoxide Mediates Angiotensin II-Induced Influx of Extracellular Calcium in Neural Cells Hypertension, April 1, 2005; 45(4): 717 - 723. [Abstract] [Full Text] [PDF]

				B.-q. Zhu, R. E Sievers, A. E. Browne, R. J Lee, K. Chatterjee, W. Grossman, J. S Karliner, and W. W Parmley Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function Journal of Renin-Angiotensin-Aldosterone System, March 1, 2003; 4(1): 31 - 37. [Abstract] [PDF]

				B.-q. Zhu, R. E Sievers, A. E. Browne, R. T Hillman, K. Chair, R. J Lee, K. Chatterjee, S. A Glantz, and W. W Parmley The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke Journal of Renin-Angiotensin-Aldosterone System, March 1, 2002; 3(1): 54 - 60. [Abstract] [PDF]

				K. Pacak and M. Palkovits Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders Endocr. Rev., August 1, 2001; 22(4): 502 - 548. [Abstract] [Full Text] [PDF]

				Y.-p. Sun, B.-q. Zhu, A. E. M. Browne, S. Pulukurthy, T. M. Chou, K. Sudhir, S. A. Glantz, P. C. Deedwania, K. Chatterjee, and W. W. Parmley Comparative Effects of ACE Inhibitors and an Angiotensin Receptor Blocker on Atherosclerosis and Vascular Function Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2001; 6(2): 175 - 181. [Abstract] [PDF]

				B.-q. Zhu, Y.-p. Sun, R. E Sievers, A. E. Browne, R. J Lee, K. Chatterjee, and W. W Parmley Effects of different durations of pretreatment with losartan on myocardial infarct size, endothelial function, and vascular endothelial growth factor Journal of Renin-Angiotensin-Aldosterone System, June 1, 2001; 2(2): 129 - 133. [Abstract] [PDF]

				B.-q. Zhu, Y.-p. Sun, R. E. Sievers, A. E. M. Browne, S. Pulukurthy, K. Sudhir, R. J. Lee, T. M. Chou, K. Chatterjee, and W. W. Parmley Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion J. Am. Coll. Cardiol., March 1, 2000; 35(3): 787 - 795. [Abstract] [Full Text] [PDF]