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Endocrinology, doi:10.1210/endo-128-2-725
Endocrinology Vol. 128, No. 2 725-727
Copyright © 1991 by the Endocrine Society.
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Lactation Abolishes Corticotropin-Releasing Factor-Induced Oxytocin Secretion in the Conscious Rat

HEMANT PATEL, HARDIAL S. CHOWDREY and STAFFORD L. LIGHTMAN

Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital London WS 8RF, United Kingdom

Abstract

We have assessed the response of plasma oxytocin (OT) to intracerebroventricular CRF-41 in both virgin female and lactating rats. In virgin rats CRF-41 resulted in an increase in plasma OT from 5–30 min after administration. In lactating rats, however, there was a complete abolition of the OT response, even at the highest dose of CRF-41. These data demonstrate another feature of the hormone nonresponsiveness apparent during lactation and suggests that one of the reasons for the lack of stress responses could be a down-regulation of the response to endogenously released CRF-41. (Endocrinology 128: 725–727, 1991)

Received September 13, 1990.




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Copyright © 1991 by The Endocrine Society