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Peptide-YY, a New Partner in the Negative Feedback Control of Pancreatic Secretion^*

D. GUAN, D. MAOUYO, I. L. TAYLOR, T. W. GETTYS, G. H. GREELEY, JR and J. MORISSET

Centre de Recherche sur les Mecanismes de Secretion, Departement de Biologie, Faculte des Sciences, Uniuersite de Sherbrooke Sherbrooke, Quebec, Canada J1K 2R1

Address all correspondence and requests for reprints to: Dr Jean Morisset, Departement de Biologie, Faculte Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1K 2R1.

Abstract

Peptide YY (PYY), a newly discovered ileocolonic peptide, is released by nutrients in the proximal and distal intestine and inhibits pancreatic secretion. However, it is not clear whether PYY can be released in the absence of nutrients in the intestine or whether a physiological role exists for endogenous PYY in negative feedback regulation of pancreatic secretion by pancreatic proteases. In the present study we measured plasma PYY concentrations and determined the effects of anti- PYY serum during stimulation of pancreatic secretion by pancreatic juice diversion (PJD). The effect of SMS 201–995 (SMS; an analog of somatostatin), another inhibitor of pancreatic secretion, on regulation of PYY release induced by PJD was also investigated. Male Wistar rats equipped with pancreatic, biliary, duodenal, and jugular venous cannulas were studied 4–6 days postoperatively. After 90 min of basal collection, pancreatic juice was diverted for 4 h with or without infusion of SMS (2 µg/kgh), given either iv or intraduodenally (ID). Plasma PYY concentrations were significantly increased from a basal level of 177 ± 15 pg/ml to a peak level of 328 ± 43 pg/ml 2 h after PJD. These increases in PYY concentration paralleled those in pancreatic protein and fluid outputs. Both iv and ID infusion of SMS during the first 2 h of PJD markedly decreased the plasma PYY concentration to 134 ± 27 pg/ml and 156 ± 19 pg/ml, respectively; the total incremental PYY release during 4 h of PJD was inhibited by 100% and 84% by iv and ID SMS, respectively. One milliliter of anti-PYY serum given iv significantly augmented the increment in protein and fluid output during PJD. These results suggest that endogenous PYY released by PJD may play a physiological role in negative feedback regulation of pancreatic secretion in rats. (Endocrinology 128: 911–916, 1991)

Footnotes

^* This work was supported by Grants A6369 and EQ733 from the Natural Sciences and Engineering Research Council of Canada and Ministere de l'Education du Quebec, and NIH Grants 37406 (to G.H.G.) and DK-38216 (to I.L.T.).

Duke University Medical Center, Duke University, Durham, North Carolina 27710.

Department of Surgery, Biochemistry Lab E26, University Texas Medical Branch, Galveston, Texas 77550.

Received August 13, 1990.

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