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Endocrinology, Vol 128, 3193-3198, Copyright © 1991 by Endocrine Society
ARTICLES |
M Hiriart and MC Ramirez-Medeles
Department of Neurosciences, Universidad Nacional Autonoma de Mexico, Mexico City.
In the present study we have used a reverse hemolytic plaque assay and frequency distribution analysis to characterize the insulin secretory response of individual rat pancreatic B-cells in culture. Heterogeneous secretory behavior was observed with a multimodal distribution, suggesting the existence of B-cell subpopulations. Insulin secretion in response to increased extracellular glucose involved both amplification of secretion by individual cells as well as recruitment of previously silent B-cells.
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