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Remembrances of the Meadowbrook Conferences—When Steroids Came to DNA

Division of Molecular Genetics, Department of Obstetrics/Gynecology, University of Texas Health Science Center

Abstract

The majestic, manorial ambience of Meadowbrook Hall—a 51-room Tudor mansion in a park-like setting amid the rolling hills of Michigan—seems an appropriate metaphor for the splendid conceptual developments in steroid hormone action that have unfolded during the last decade. With the first availability of recombinant DNA technology for endocrinological investigation, we all felt a pleasant tension of excitement and anticipation—certain that something more than ambiguous conclusions based on an endless array of sucrose gradient peaks was about to emerge. Many long-time workers in the field experienced a less pleasant, albeit needless, tension as well: the fear that "retooling" for the new technology would prove an insurmountable difficulty and that the entire field in which they had labored so long would be engulfed by the domain of microbiology and virology. The previous two decades had seen the rise and fall of two well publicized dogmas: Paul Talalay's transhydrogenation model and Gordon Tomkins' posttranscription model.

Footnotes

"Remembrance" articles discuss people and events as remembered by the author. The opinion(s) expressed are solely those of the writer and do not reflect the view of the Journal or The Endocrine Society.

Received February 12, 1991.