help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology, doi:10.1210/endo-129-2-785
Endocrinology Vol. 129, No. 2 785-791
Copyright © 1991 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by OLSON, B. R.
Right arrow Articles by VERBALIS, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by OLSON, B. R.
Right arrow Articles by VERBALIS, J. G.

Brain Oxytocin Receptor Antagonism Blunts the Effects of Anorexigenic Treatments in Rats: Evidence for Central Oxytocin Inhibition of Food Intake*

BEATRIZ R. OLSON{dagger}, MARCIA D. DRUTAROSKY, EDWARD M. STRICKER and JOSEPH G. VERBALIS

Departments of Medicine and Behavioral Neuroscience, University of Pittsburgh Pittsburgh, Pennsylvania 15261

Address all correspondence and requests for reprints to: Dr. Beatriz R. Olson, Department of Medicine, E-1140 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

Abstract

The inhibition of food intake in rats that results from various anorexigenic treatments is frequently associated with pituitary secretion of oxytocin (OT), but is not caused by circulating OT. We, therefore, evaluated the potential role of brain OT in mediating anorexia induced in rats by systemic administration of cholecystokinin (CCK), hypertonic saline (HS), or lithium chloride (LiCl), treatments that are known to stimulate pituitary OT secretion as well as to inhibit food intake. Food intake was analyzed in 22-h food-deprived rats pretreated with icv injections of either artificial cerebrospinal fluid (aCSF) or 9 nmol of an OT receptor antagonist, [d(CH2)5, Tyr(OMe)2, Orn8] vasotocin (OVT), which was the dose found to be most effective to antagonize the anorexia induced by CCK and HS. Pretreatment with the OT receptor antagonist icv significantly blunted the anorexigenic effect of each agent. After CCK (10 µg/kg, ip), food intake increased from 28 ± 5% of basal intake after aCSF icv to 48 ± 8% after OVT icv (P < 0.01); after HS (2 ml 2 M NaCl, ip), food intake increased from 9 ± 4% of basal intake after aCSF icv to 43 ± 7% after OVT icv (P < 0.01); and after LiCl (1.125 mmol/kg, ip), food intake increased from 55 ± 4% of basal intake after aCSF icv to 80 ± 9% after OVT icv (P < 0.01). These data support the hypothesis that pituitary secretion of OT after anorexigenic treatments in rats is associated with coactivation of centrally projecting brain OT pathways, some of which are causally related to the induced inhibition of food intake.

Footnotes

* This work was supported in part by NIH Research Grant MH-25140 (MERIT Award). These data were presented in preliminary form at the 19th Annual Meeting of the Society for Neuroscience, Phoenix, AZ, November 1989.

{dagger} Fellow in Endocrinology and Metabolism at the Department of Medicine, University of Pittsburgh.

Received January 29, 1991.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Schroeder, O. Zagoory-Sharon, L. Shbiro, A. Marco, J. Hyun, T. H. Moran, S. Bi, and A. Weller
Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2009; 297(6): R1749 - R1760.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Kohno, M. Nakata, Y. Maejima, H. Shimizu, U. Sedbazar, N. Yoshida, K. Dezaki, T. Onaka, M. Mori, and T. Yada
Nesfatin-1 Neurons in Paraventricular and Supraoptic Nuclei of the Rat Hypothalamus Coexpress Oxytocin and Vasopressin and Are Activated by Refeeding
Endocrinology, March 1, 2008; 149(3): 1295 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. D. Hoyda, M. Fry, R. S. Ahima, and A. V. Ferguson
Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus
J. Physiol., December 15, 2007; 585(3): 805 - 816.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. O. Mack, M. Wu, P. Kc, and M. A. Haxhiu
Stimulation of the hypothalamic paraventricular nucleus modulates cardiorespiratory responses via oxytocinergic innervation of neurons in pre-Botzinger complex
J Appl Physiol, January 1, 2007; 102(1): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. A. Bechtold and S. M. Luckman
Prolactin-Releasing Peptide Mediates Cholecystokinin-Induced Satiety in Mice
Endocrinology, October 1, 2006; 147(10): 4723 - 4729.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Malcher-Lopes, S. Di, V. S. Marcheselli, F.-J. Weng, C. T. Stuart, N. G. Bazan, and J. G. Tasker
Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release.
J. Neurosci., June 14, 2006; 26(24): 6643 - 6650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. A. Amico, R. R. Vollmer, H.-m. Cai, J. A. Miedlar, and L. Rinaman
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1798 - R1806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Rinaman, R. R. Vollmer, J. Karam, D. Phillips, X. Li, and J. A. Amico
Dehydration anorexia is attenuated in oxytocin-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1791 - R1799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Blevins, M. W. Schwartz, and D. G. Baskin
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R87 - R96.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Brighton, P. G. Szekeres, and G. B. Willars
Neuromedin U and Its Receptors: Structure, Function, and Physiological Roles
Pharmacol. Rev., June 1, 2004; 56(2): 231 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
Y. Ueta, Y. Ozaki, J. Saito, and T. Onaka
Involvement of Novel Feeding-Related Peptides in Neuroendocrine Response to Stress
Experimental Biology and Medicine, November 1, 2003; 228(10): 1168 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. C. Mantella, L. Rinaman, R. R. Vollmer, and J. A. Amico
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1037 - R1045.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Vrang, C. B. Phifer, M. M. Corkern, and H.-R. Berthoud
Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R470 - R478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Salter and A. G. Watts
Differential suppression of hyperglycemic, feeding, and neuroendocrine responses in anorexia
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R174 - R182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Rinaman and E. E. Rothe
GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R99 - R106.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. E. Shade, J. R. Blair-West, K. D. Carey, L. J. Madden, R. S. Weisinger, J. E. Rivier, W. W. Vale, and D. A. Denton
Ingestive responses to administration of stress hormones in baboons
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R10 - R18.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Billig, B. J. Yates, and L. Rinaman
Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1243 - R1255.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. Gimpl and F. Fahrenholz
The Oxytocin Receptor System: Structure, Function, and Regulation
Physiol Rev, April 1, 2001; 81(2): 629 - 683.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Vrang, P. J. Larsen, P. Kristensen, and M. Tang-Christensen
Central Administration of Cocaine-Amphetamine-Regulated Transcript Activates Hypothalamic Neuroendocrine Neurons in the Rat
Endocrinology, February 1, 2000; 141(2): 794 - 801.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Rinaman
A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1537 - R1540.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. S. Curtis, W. Huang, A. F. Sved, J. G. Verbalis, and E. M. Stricker
Impaired osmoregulatory responses in rats with area postrema lesions
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R209 - R219.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society