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The Backstage Story of the Discovery of LHRH

Abstract

During my postdoctoral years (1956-1961) spent first at Yale University and then at Tulane University, I was fortunate to become acquainted with many talented endocrinologists. At that time, my major interest was the role of vasopressin in stimulating ACTH secretion. Vasopressin was then one of the strongest candidates for CRF, as advocated by Don McCann. Roger Guillemin and Andrew Serially claimed the existence of separate CRF-a and CRF-β molecules. At Tulane University I worked with Joseph Dingman in the Department of Medicine where I tried to establish a method for separating vasopressin from human plasma using glass fiber paper chromatography. In 1960, on the way home from Miami after attending the Annual Endocrinology Meeting, I happened to board the plane with Schally. He showed a considerable interest in the chromatographic method on which I was working. We talked enthusiastically about CRF and he emphatically denied the possibility that vasopressin was CRF. During my stay in New Orleans, I visited Guillemin and Schally at Baylor College a couple of times. In contrast to Guillemin, a European professor type, Schally was always working feverishly beside his column. One day when I visited him he was watching the column-electrophoresis with reddened eyes, telling me that he watched the column to purify CRF for 2 days without sleep. I began to feel sympathy with Schally, thinking that some day I could help him.

Received April 9, 1991.

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