Endocrinology, Vol 129, 2254-2256, Copyright © 1991 by Endocrine Society

ARTICLES

Insulin-like growth factor-binding protein-1 modulates blood glucose levels

MS Lewitt, GS Denyer, GJ Cooney and RC Baxter
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, N.S.W., Australia.

We have determined the consequences of insulin-like growth factor- binding protein-1 (IGFBP-1) administration alone and in combination with insulin-like growth factor-I (IGF-I). Human recombinant IGF-I, infused as a bolus into male Wistar rats, induced a fall in plasma glucose to 72 +/- 3% of baseline 15 min after injection. Co-infusion of equimolar concentrations of human IGFBP-1 abolished the IGF-I-induced fall (P less than 0.001). Injection of IGFBP-1 alone caused a rise in plasma glucose levels (P less than 0.002). The half life of human IGFBP- 1, measured using a primate-specific RIA, was 12.5 +/- 0.7 min and was not influenced by the co-infusion of IGF-I. This study demonstrates that, in the rat, human IGFBP-1 blocks the hypoglycemic response to intravenous IGF-I and increases blood glucose levels when administered alone. Since IGFBP-1 concentrations are dependent on metabolic status, we suggest that fluctuating IGFBP-1 levels might modulate the hypoglycemic activity of unbound IGFs in the circulation.

This article has been cited by other articles:

				U Berg, T Gustafsson, C J Sundberg, L Kaijser, C Carlsson-Skwirut, and P Bang Interstitial IGF-I in exercising skeletal muscle in women Eur. J. Endocrinol., October 1, 2007; 157(4): 427 - 435. [Abstract] [Full Text] [PDF]

				Y. Ning, A. G. P. Schuller, S. Bradshaw, P. Rotwein, T. Ludwig, J. Frystyk, and J. E. Pintar Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -5 Mol. Endocrinol., September 1, 2006; 20(9): 2173 - 2186. [Abstract] [Full Text] [PDF]

				J.-W. Chen, M. F Nielsen, A. Caumo, H. Vilstrup, J. S. Christiansen, and J. Frystyk Changes in bioactive IGF-I and IGF-binding protein-1 during an oral glucose tolerance test in patients with liver cirrhosis. Eur. J. Endocrinol., August 1, 2006; 155(2): 285 - 292. [Abstract] [Full Text] [PDF]

				V. Roelfsema, A. J. Gunn, B. H. Breier, J. S. Quaedackers, and L. Bennet The Effect of Mild Hypothermia on Insulin-like Growth Factors After Severe Asphyxia in the Preterm Fetal Sheep Reproductive Sciences, May 1, 2005; 12(4): 232 - 237. [Abstract] [PDF]

				J. D. Veldhuis, J. Frystyk, A. Iranmanesh, and H. Orskov Testosterone and Estradiol Regulate Free Insulin-Like Growth Factor I (IGF-I), IGF Binding Protein 1 (IGFBP-1), and Dimeric IGF-I/IGFBP-1 Concentrations J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2941 - 2947. [Abstract] [Full Text] [PDF]

				K.-C. Leung, G. Johannsson, G. M. Leong, and K. K. Y. Ho Estrogen Regulation of Growth Hormone Action Endocr. Rev., October 1, 2004; 25(5): 693 - 721. [Abstract] [Full Text] [PDF]

				D. Nemet, P. H. Connolly, A. M. Pontello-Pescatello, C. Rose-Gottron, J. K. Larson, P. Galassetti, and D. M. Cooper Negative energy balance plays a major role in the IGF-I response to exercise training J Appl Physiol, January 1, 2004; 96(1): 276 - 282. [Abstract] [Full Text] [PDF]

				C. H. Lang, T. C. Vary, and R. A. Frost Acute in Vivo Elevation of Insulin-Like Growth Factor (IGF) Binding Protein-1 Decreases Plasma Free IGF-I and Muscle Protein Synthesis Endocrinology, September 1, 2003; 144(9): 3922 - 3933. [Abstract] [Full Text] [PDF]

				J. V. Silha, Y. Gui, and L. J. Murphy Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E937 - E945. [Abstract] [Full Text] [PDF]

				J. Manetta, J. F. Brun, L. Maimoun, A. Callis, C. Prefaut, and J. Mercier Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E929 - E936. [Abstract] [Full Text] [PDF]

				J. Verhaeghe, A. Pintiaux, E. van Herck, G. Hennen, J.-M. Foidart, and A. Igout Placental GH, IGF-I, IGF-Binding Protein-1, and Leptin during a Glucose Challenge Test in Pregnant Women: Relation with Maternal Body Weight, Glucose Tolerance, and Birth Weight J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2875 - 2882. [Abstract] [Full Text] [PDF]

				L. E. L. Katz, D. D. DeLeon, H. Zhao, and A. F. Jawad Free and Total Insulin-Like Growth Factor (IGF)-I Levels Decline during Fasting: Relationships with Insulin and IGF-Binding Protein-1 J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2978 - 2983. [Abstract] [Full Text] [PDF]

				S. M. Firth, F. MCDougall, A. J. MCLachlan, and R. C. Baxter Impaired Blockade of Insulin-Like Growth Factor I (IGF-I)-Induced Hypoglycemia by IGF Binding Protein-3 Analog with Reduced Ternary Complex-Forming Ability Endocrinology, May 1, 2002; 143(5): 1669 - 1676. [Abstract] [Full Text] [PDF]

				K. Sakai, H. B. Lowman, and D. R. Clemmons Increases in Free, Unbound Insulin-like Growth Factor I Enhance Insulin Responsiveness in Human Hepatoma G2 Cells in Culture J. Biol. Chem., April 12, 2002; 277(16): 13620 - 13627. [Abstract] [Full Text] [PDF]

				E. C. Crowne, J. S. Samra, T. Cheetham, C. L. Acerini, A. Watts, J. M. P. Holly, and D. B. Dunger The Role of IGF-Binding Proteins in Mediating the Effects of Recombinant Human IGF-I on Insulin Requirements in Type 1 Diabetes Mellitus J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3686 - 3691. [Abstract] [Full Text] [PDF]

				T. G. Anthony, J. C. Anthony, M. S. Lewitt, S. M. Donovan, and D. K. Layman Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats Am J Physiol Endocrinol Metab, April 1, 2001; 280(4): E650 - E656. [Abstract] [Full Text] [PDF]

				K. Sakai, A. J. D'Ercole, L. J. Murphy, and D. R. Clemmons Physiological Differences in Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Phosphorylation in IGFBP-1 Transgenic Mice Diabetes, January 1, 2001; 50(1): 32 - 38. [Abstract] [Full Text]

				R. C. Baxter Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E967 - E976. [Abstract] [Full Text] [PDF]

				D. R. Clemmons, A. C. Moses, M. J. McKay, A. Sommer, D. M. Rosen, and J. Ruckle The Combination of Insulin-Like Growth Factor I and Insulin-Like Growth Factor-Binding Protein-3 Reduces Insulin Requirements in Insulin-Dependent Type 1 Diabetes: Evidence for in VivoBiological Activity J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1518 - 1524. [Abstract] [Full Text]

				S. C. van Buul-Offers, M. van Kleffens, J. G. Koster, D. J. Lindenbergh-Kortleve, M. G. Gresnigt, S. L. S. Drop, C. M. Hoogerbrugge, R. J. Bloemen, J. A. Koedam, and J. W. van Neck Human Insulin-Like Growth Factor (IGF) Binding Protein-1 Inhibits IGF-I-Stimulated Body Growth but Stimulates Growth of the Kidney in Snell Dwarf Mice Endocrinology, April 1, 2000; 141(4): 1493 - 1499. [Abstract] [Full Text] [PDF]

				M. R. SCHNEIDER, H. LAHM, M. WU, A. HOEFLICH, and E. WOLF Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins FASEB J, April 1, 2000; 14(5): 629 - 640. [Abstract] [Full Text]

				M. Tomizawa, A. Kumar, V. Perrot, J. Nakae, D. Accili, and M. M. Rechler Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR. A MECHANISM FOR INSULIN INHIBITION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 TRANSCRIPTION J. Biol. Chem., March 15, 2000; 275(10): 7289 - 7295. [Abstract] [Full Text] [PDF]

				R. P Holmes, J M P Holly, and P. W Soothill Maternal insulin-like growth factor binding protein-1, body mass index, and fetal growth Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2000; 82(2): 113F - 117. [Abstract] [Full Text]

				J. C. D. Filho, S. J. Hazel, B. Anderstam, J. Bergstrom, M. Lewitt, and K. Hall Effect of protein intake on plasma and erythrocyte free amino acids and serum IGF-I and IGFBP-1 levels in rats Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E693 - E701. [Abstract] [Full Text] [PDF]

				R. A. Frost and C. H. Lang Differential Effects of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 on Protein Metabolism in Human Skeletal Muscle Cells Endocrinology, September 1, 1999; 140(9): 3962 - 3970. [Abstract] [Full Text]

				S. Cianfarani, D. Germani, and F. Branca Low birthweight and adult insulin resistance: the "catch-up growth" hypothesis Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1999; 81(1): 71F - 73. [Full Text]

				R. C. Baxter Comment--Do Glucocorticoids Mediate the Hypoglycemia-Induced Rise in Insulin-Like Growth Factor Binding Protein-1? J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2259 - 2261. [Full Text]

				L. E. Levitt Katz, M. S. Satin-Smith, P. Collett-Solberg, L. Baker, C. A. Stanley, and P. Cohen Dual Regulation of Insulin-Like Growth Factor Binding Protein-1 Levels by Insulin and Cortisol during Fasting J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4426 - 4430. [Abstract] [Full Text]

				M. E. Wilson Effects of Estradiol and Exogenous Insulin-Like Growth Factor I (IGF-I) on the IGF-I Axis during Growth Hormone Inhibition and Antagonism J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 4013 - 4021. [Abstract] [Full Text]

				A. Barreca, M. Bozzola, A. Cesarone, P. H. Steenbergh, P. E. Holthuizen, F. Severi, G. Giordano, and F. Minuto Short Stature Associated with High Circulating Insulin-Like Growth Factor (IGF)-Binding Protein-1 and Low Circulating IGF-II: Effect of Growth Hormone Therapy J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3534 - 3541. [Abstract] [Full Text]

				C. Skjærbæk, J. Frystyk, H. Ørskov, P. Kissmeyer-Nielsen, M. B. Jensen, S. Laurberg, N. Møller, and A. Flyvbjerg Differential Changes in Free and Total Insulin-Like Growth Factor I after Major, Elective Abdominal Surgery: The Possible Role of Insulin-Like Growth Factor-Binding Protein-3 Proteolysis J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2445 - 2449. [Abstract] [Full Text]

				D.-S. Suh and M. M. Rechler Hepatocyte Nuclear Factor 1 and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat Insulin-like Growth Factor Binding Protein-1 Gene Mol. Endocrinol., November 1, 1997; 11(12): 1822 - 1831. [Abstract] [Full Text]

				J. A. M. J. L. Janssen, M. L. Jacobs, F. H. M. Derkx, R. F. A. Weber, A. J. van der Lely, and S. W. J. Lamberts Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 (IGFBP-1), and IGFBP-3 and Their Relationships to the Presence of Diabetic Retinopathy and Glomerular Hyperfiltration in Insulin-Dependent Diabetes Mellitus J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2809 - 2815. [Abstract] [Full Text] [PDF]

				J. Frystyk, T. Grofte, C. Skjarbak, and H. Orskov The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3124 - 3127. [Abstract] [Full Text] [PDF]

				K. Berneis, R. Ninnis, J. Girard, B. M. Frey, and U. Keller Effects of Insulin-Like Growth Factor I Combined with Growth Hormone on Glucocorticoid-Induced Whole-Body Protein Catabolism in Man J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2528 - 2534. [Abstract] [Full Text] [PDF]

				E. Fernqvist-Forbes, A. Hilding, K. Ekberg, and K. Brismar Influence of Circulating Epinephrine and Norepinephrine on Insulin-Like Growth Factor Binding Protein-1 in Humans J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2677 - 2680. [Abstract] [Full Text] [PDF]

				B. L. G. Nyomba, L. Berard, and L. J. Murphy Free Insulin-Like Growth Factor I (IGF-I) in Healthy Subjects: Relationship with IGF-Binding Proteins and Insulin Sensitivity J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2177 - 2181. [Abstract] [Full Text] [PDF]

				C. A. Benbassat, K. C. Maki, and T. G. Unterman Circulating Levels of Insulin-Like Growth Factor (IGF) Binding Protein-1 and -3 in Aging Men: Relationships to Insulin, Glucose, IGF, and Dehydroepiandrosterone Sulfate Levels and Anthropometric Measures J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1484 - 1491. [Abstract] [Full Text] [PDF]

				D. L. Mortensen, W. B. Won, J. Siu, D. Reifsnyder, M. Gironella, T. Etcheverry, and R. G. Clark Insulin-Like Growth Factor Binding Protein-1 Induces Insulin Release in the Rat Endocrinology, May 1, 1997; 138(5): 2073 - 2080. [Abstract] [Full Text] [PDF]

				K. Thrailkill, T. Quattrin, L. Baker, J. Litton, K. Dwigun, M. Rearson, M. Poppenheimer, D. Kotlovker, D. Giltinan, N. Gesundheit, et al. Dual Hormonal Replacement Therapy with Insulin and Recombinant Human Insulin-Like Growth Factor (IGF)-I in Insulin-Dependent Diabetes Mellitus: Effects on the Growth Hormone/IGF/IGF-Binding Protein System J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1181 - 1187. [Abstract] [Full Text] [PDF]

				R. V. Bhat, T. M. Engber, Y. Zhu, M. S. Miller, and P. C. Contreras Identification of Insulin-Like Growth Factor Binding Protein-2 as a Biochemical Surrogate Marker for the in Vivo Effects of Recombinant Human Insulin-Like Growth Factor-1 in Mice J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 522 - 530. [Abstract] [Full Text]

				M. J. Khosravi, A. Diamandi, and J. Mistry Immunoassay of insulin-like growth factor binding protein-1 Clin. Chem., March 1, 1997; 43(3): 523 - 532. [Abstract] [Full Text] [PDF]

				C. J. Band and B. I. Posner Phosphatidylinositol 3'-Kinase and p70s6k Are Required for Insulin but Not Bisperoxovanadium 1,10-Phenanthroline (bpV(phen)) Inhibition of Insulin-like Growth Factor Binding Protein Gene Expression. EVIDENCE FOR MEK-INDEPENDENT ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASE BY bpV(phen) J. Biol. Chem., January 3, 1997; 272(1): 138 - 145. [Abstract] [Full Text] [PDF]

				E. Carmina, F. Z. Stanczyk, R. S. Morris, P. D. K. Lee, G. Savjani, and R. A. Lobo Altered Regulation of Insulin-Like Growth Factor Binding Protein-I in Patients With Polycystic Ovary Syndrome Reproductive Sciences, November 1, 1995; 2(6): 743 - 747. [Abstract] [PDF]