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Endocrinology, Vol 129, 2263-2265, Copyright © 1991 by Endocrine Society

ARTICLES

Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family

RB Mackin, BD Noe and J Spiess
Dept. of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Gottingen, Germany.

A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.


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