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Remembrance of Dr. Alfred Jost

Dr. Alfred Jost died suddenly at his home, in the early morning of February 3, 1991, of a heart attack, at the age of 74. Just retired from the College of France, a prestigious school for higher education, he was still active in research, in spite of the demands made on his time by his duties as secretary of the French Academy of Science. Dr. Jost is rightly regarded as the father of modern fetal endocrinology. Up to 1950, birds were the favorite embryological models, because of the technical accessibility of the avian egg. Jost was the first to apply surgical techniques to the intrauterine mammalian fetus. By castrating fetal rabbits at an early, ambivalent stage, he succeeded in preventing male differentiation: the genetic males were born with persistent Miillerian ducts and no Wolffian derivatives (1).

Received May 29, 1991.