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Endocrinology, doi:10.1210/endo-129-5-2325
Endocrinology Vol. 129, No. 5 2325-2328
Copyright © 1991 by the Endocrine Society.
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Pituitary-Placental Interaction: Hypophysectomy Modulates the Secretion of Mouse Placental Lactogen-I*

MARY FRANCES LOPEZ, FRANCISCO ALONZO CARRION{dagger} and FRANK TALAMANTES

Department of Biology, Sinsheimer Laboratories, University of California Santa Cruz, California 95064

Address all correspondence and requests for reprints to: Dr. Frank Talamantes, Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064.

Abstract

To determine whether the pituitary gland influences the concentration of mouse placental lactogen-I (mPL-I) in maternal serum, pregnant Swiss Webster mice were hypophysectomized or sham-operated on day 9 of gestation. Blood was collected on days 10–13 and 18, and the mPL-I concentration of the serum was measured by RIA. The serum mPL-I concentration of hypophysectomized mice was significantly higher than that of sham-operated and intact mice on days 10–13. There was no difference in mPL-I concentration on day 18 of pregnancy among the groups. Similar elevations in serum mPL-I concentration were observed when hypophysectomy was performed on day 10 of pregnancy. Steady state levels of placental mPL-I messenger RNA (mRNA) were analyzed by Northern hybridization. No differences were observed in the amount of mPL-I mRNA among hypophysectomized, sham-operated, and intact mice. These results demonstrate that the pituitary gland exerts inhibitory control over the maternal serum mPL-I concentration. This control does not appear to be affected at the level of steady state amounts of mPL-I mRNA. (Endocrinology 129: 2325–2328,1991)

Footnotes

* This work was supported by NIH Grants HD-14966 and RR-08132 to Dr. Frank Talamantes.

{dagger} Bioquimica y Biologia Molecular, Universidad de Malaga, Facultad de Ciencias, Campus de Teatinos, Malaga, Spain 29071.

Received May 3, 1991.






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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1991 by The Endocrine Society