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Endocrinology, Vol 129, 2793-2795, Copyright © 1991 by Endocrine Society
ARTICLES |
SJ Ringstrom, JM McAndrews, JO Rahal and NB Schwartz
Department of Neurobiology, Northwestern University, Evanston, Il 60208.
Cortisol treatment for 6 or 12 days had no effect on serum FSH in intact males and animals castrated for 1 or 7 days, but pituitary FSH was increased by the steroid in both intact and castrate groups. In contrast, cortisol inhibited serum LH in both intact and castrated animals while only increasing pituitary levels of LH in 7 day castrates. Cortisol also increased the mRNA for FSH beta without affecting alpha or LH beta mRNAs. These data suggest that the selective increase in pituitary content of FSH may be due to a selective increase in FSH beta mRNA following exposure to cortisol.
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