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Endocrinology, Vol 130, 229-239, Copyright © 1992 by Endocrine Society

ARTICLES

Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide

S Suga, K Nakao, K Hosoda, M Mukoyama, Y Ogawa, G Shirakami, H Arai, Y Saito, Y Kambayashi and K Inouye
Department of Medicine, Kyoto University School of Medicine, Japan.

To elucidate the ligand-receptor relationship of the natriuretic peptide system, which comprises at least three endogenous ligands, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and three receptors, the ANP-A receptor or guanylate cyclase-A (GC-A), the ANP-B receptor or guanylate cyclase-B (GC-B), and the clearance receptor (C-receptor), we characterized the receptor preparations from human, bovine, and rat tissues and cultured cells with the aid of the binding assay, Northern blot technique, and the cGMP production method. Using these receptor preparations, we examined the binding affinities of ANP, BNP, and CNP for the C-receptor and their potencies for cGMP production via the ANP- A receptor (GC-A) and the ANP-B receptor (GC-B). These analyses revealed the presence of a marked species difference in the receptor selectivity of the natriuretic peptide family, especially among BNPs. Therefore, we investigated the receptor selectivity of the natriuretic peptide family using the homologous assay system with endogenous ligands and receptors of the same species. The rank order of binding affinity for the C-receptor was ANP greater than CNP greater than BNP in both humans and rats. The rank order of potency for cGMP production via the ANP-A receptor (GC-A) was ANP greater than or equal to BNP much greater than CNP, but that via the ANP-B receptor (GC-B) was CNP greater than ANP greater than or equal to BNP. These findings on the receptor selectivity of the natriuretic peptide family provide a new insight into the understanding of the physiological and clinical implications of the natriuretic peptide system.


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Home page
 EndocrinologyHome page
H. Chusho, Y. Ogawa, N. Tamura, M. Suda, A. Yasoda, T. Miyazawa, I. Kishimoto, Y. Komatsu, H. Itoh, K. Tanaka, et al.
Genetic Models Reveal That Brain Natriuretic Peptide Can Signal through Different Tissue-Specific Receptor-Mediated Pathways
Endocrinology, October 1, 2000; 141(10): 3807 - 3813.
[Abstract] [Full Text] [PDF]

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 J. Am. Soc. Nephrol.Home page
M. KASAHARA, M. MUKOYAMA, A. SUGAWARA, H. MAKINO, T. SUGANAMI, Y. OGAWA, M. NAKAGAWA, K. YAHATA, M. GOTO, R. ISHIBASHI, et al.
Ameliorated Glomerular Injury in Mice Overexpressing Brain Natriuretic Peptide with Renal Ablation
J. Am. Soc. Nephrol., September 1, 2000; 11(9): 1691 - 1701.
[Abstract] [Full Text]

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 J. Pharmacol. Exp. Ther.Home page
G. J. Trachte
Depletion of Natriuretic Peptide C Receptors Eliminates Inhibitory Effects of C-Type Natriuretic Peptide on Evoked Neurotransmitter Efflux
J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 210 - 215.
[Abstract] [Full Text]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. S. Murthy, B.-Q. Teng, H. Zhou, J.-G. Jin, J. R. Grider, and G. M. Makhlouf
Gi-1/Gi-2-dependent signaling by single-transmembrane natriuretic peptide clearance receptor
Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G974 - G980.
[Abstract] [Full Text] [PDF]

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 J Am Coll CardiolHome page
J. A. Schirger, J. A. Grantham, I. J. Kullo, M. Jougasaki, P. W. Wennberg, H. H. Chen, O. Lisy, V. Miller, R. D. Simari, and J. C. Burnett Jr.
Vascular actions of brain natriuretic peptide: modulation by atherosclerosis and neutral endopeptidase inhibition
J. Am. Coll. Cardiol., March 1, 2000; 35(3): 796 - 801.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
A. Noubani, R. Farookhi, and J. Gutkowska
B-Type Natriuretic Peptide Receptor Expression and Activity Are Hormonally Regulated in Rat Ovarian Cells
Endocrinology, February 1, 2000; 141(2): 551 - 559.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Z. Kim, K. W. Cho, and S. H. Kim
Modulation of endocardial natriuretic peptide receptors in right ventricular hypertrophy
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2280 - H2289.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. Jaubert, F. Jaubert, N. Martin, L. L. Washburn, B. K. Lee, E. M. Eicher, and J.-L. Guenet
Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3)
PNAS, August 31, 1999; 96(18): 10278 - 10283.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Itoh, J. Zheng, I. M. Bird, K. Nakao, and R. R. Magness
Basic FGF decreases clearance receptor of natriuretic peptides in fetoplacental artery endothelium
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1999; 277(2): R541 - R547.
[Abstract] [Full Text] [PDF]

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 J. Physiol.Home page
J. I Kourie
Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithorhynchus anatinus) venom
J. Physiol., July 15, 1999; 518(2): 359 - 369.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
J. Gutkowska, M. Jankowski, M. Ram Sairam, N. Fujio, A. M. Reis, S. Mukaddam-Daher, and J. Tremblay
Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat
Biol Reprod, July 1, 1999; 61(1): 162 - 170.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
N. Matsukawa, W. J. Grzesik, N. Takahashi, K. N. Pandey, S. Pang, M. Yamauchi, and O. Smithies
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
PNAS, June 22, 1999; 96(13): 7403 - 7408.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. S. Murthy and G. M. Makhlouf
Identification of the G Protein-activating Domain of the Natriuretic Peptide Clearance Receptor (NPR-C)
J. Biol. Chem., June 18, 1999; 274(25): 17587 - 17592.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. L. Woods and M. J. M. Jones
Atrial, B-type, and C-type natriuretic peptides cause mesenteric vasoconstriction in conscious dogs
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1443 - R1452.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Labrecque, N. Mc Nicoll, M. Marquis, and A. De Lean
A Disulfide-bridged Mutant of Natriuretic Peptide Receptor-A Displays Constitutive Activity. ROLE OF RECEPTOR DIMERIZATION IN SIGNAL TRANSDUCTION
J. Biol. Chem., April 2, 1999; 274(14): 9752 - 9759.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
D. Brenner and R. Gerstberger
Functional Receptors in the Avian Kidney for C-Type Natriuretic Peptide
Endocrinology, April 1, 1999; 140(4): 1622 - 1629.
[Abstract] [Full Text]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Zellner, A. A. Protter, E. Ko, M. R. Pothireddy, T. DeMarco, S. J. Hutchison, T. M. Chou, K. Chatterjee, and K. Sudhir
Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1049 - H1057.
[Abstract] [Full Text] [PDF]

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 HypertensionHome page
S. Takida, B. J. Elmquist, and G. J. Trachte
C-Type Natriuretic Peptide Attenuates Evoked Dopamine Efflux by Influencing Go{alpha}
Hypertension, January 1, 1999; 33(1): 124 - 129.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
K. S. Murthy, B.-Q. Teng, J.-G. Jin, and G. M. Makhlouf
G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor
Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1409 - C1416.
[Abstract] [Full Text] [PDF]

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 Arterioscler. Thromb. Vasc. Bio.Home page
J. L. Bouchie, H. Hansen, and E. P. Feener
Natriuretic Factors and Nitric Oxide Suppress Plasminogen Activator Inhibitor-1 Expression in Vascular Smooth Muscle Cells : Role of cGMP in the Regulation of the Plasminogen System
Arterioscler Thromb Vasc Biol, November 1, 1998; 18(11): 1771 - 1779.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
H. Itoh, I. M. Bird, K. Nakao, and R. R. Magness
Pregnancy Increases Soluble and Particulate Guanylate Cyclases and Decreases the Clearance Receptor of Natriuretic Peptides in Ovine Uterine, But Not Systemic, Arteries
Endocrinology, July 1, 1998; 139(7): 3329 - 3341.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Yasoda, Y. Ogawa, M. Suda, N. Tamura, K. Mori, Y. Sakuma, H. Chusho, K. Shiota, K. Tanaka, and K. Nakao
Natriuretic Peptide Regulation of Endochondral Ossification. EVIDENCE FOR POSSIBLE ROLES OF THE C-TYPE NATRIURETIC PEPTIDE/GUANYLYL CYCLASE-B PATHWAY
J. Biol. Chem., May 8, 1998; 273(19): 11695 - 11700.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
S.-i. Suga, H. Itoh, Y. Komatsu, H. Ishida, T. Igaki, J. Yamashita, K. Doi, T.-H. Chun, T. Yoshimasa, I. Tanaka, et al.
Regulation of Endothelial Production of C-Type Natriuretic Peptide by Interaction between Endothelial Cells and Macrophages
Endocrinology, April 1, 1998; 139(4): 1920 - 1926.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Suda, Y. Ogawa, K. Tanaka, N. Tamura, A. Yasoda, T. Takigawa, M. Uehira, H. Nishimoto, H. Itoh, Y. Saito, et al.
Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide
PNAS, March 3, 1998; 95(5): 2337 - 2342.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. Fujishige, N. Yanaka, H. Akatsuka, and K. Omori
Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L425 - L431.
[Abstract] [Full Text] [PDF]

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 HypertensionHome page
G. Barletta, C. Lazzeri, S. Vecchiarino, R. Del Bene, G. Messeri, A. Dello Sbarba, M. Mannelli, and G. La Villa
Low-Dose C-Type Natriuretic Peptide Does Not Affect Cardiac and Renal Function in Humans
Hypertension, March 1, 1998; 31(3): 802 - 808.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
P. Vaillancourt, S. Omer, X.-F. Deng, S. Mulay, and D. R. Varma
Differential effects of rat pregnancy on uterine and lung atrial natriuretic factor receptors
Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E52 - E56.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
K. T. Jensen, J. Carstens, and E. B. Pedersen
Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans
Am J Physiol Renal Physiol, January 1, 1998; 274(1): F63 - F72.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
S. Kanwal, B. J. Elmquist, and G. J. Trachte
Atrial Natriuretic Peptide Inhibits Evoked Catecholamine Release by Altering Sensitivity to Calcium
J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 426 - 433.
[Abstract] [Full Text]

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 Circ. Res.Home page
M. Kohno, K. Yokokawa, K. Yasunari, H. Kano, M. Minami, M. Ueda, and J. Yoshikawa
Effect of Natriuretic Peptide Family on the Oxidized LDL–Induced Migration of Human Coronary Artery Smooth Muscle Cells
Circ. Res., October 19, 1997; 81(4): 585 - 590.
[Abstract] [Full Text]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Pham, S. Sediame, G. Maistre, F. Roudot-Thoraval, P.-E. Chabrier, A. Carayon, and S. Adnot
Renal and vascular effects of C-type and atrial natriuretic peptides in humans
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1457 - R1464.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. J. Lopez, D. L. Garbers, and M. Kuhn
The Guanylyl Cyclase-deficient Mouse Defines Differential Pathways of Natriuretic Peptide Signaling
J. Biol. Chem., September 12, 1997; 272(37): 23064 - 23068.
[Abstract] [Full Text] [PDF]

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 HypertensionHome page
M. Goto, M. Mukoyama, S.-i. Suga, T. Matsumoto, M. Nakagawa, R. Ishibashi, M. Kasahara, A. Sugawara, I. Tanaka, and K. Nakao
Growth-Dependent Induction of Angiotensin II Type 2 Receptor in Rat Mesangial Cells
Hypertension, September 1, 1997; 30(3): 358 - 362.
[Abstract] [Full Text]

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 HypertensionHome page
R. R. Brandt, M. T. Mattingly, A. L. Clavell, P. L. Barclay, and J. C. Burnett Jr
Neutral Endopeptidase Regulates C-Type Natriuretic Peptide Metabolism But Does Not Potentiate Its Bioactivity In Vivo
Hypertension, August 1, 1997; 30(2): 184 - 190.
[Abstract] [Full Text]


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