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Endocrinology, Vol 130, 1077-1079, Copyright © 1992 by Endocrine Society

ARTICLES

Expression of thyroid hormone receptor beta 2 in rat hypothalamus

CB Cook, I Kakucska, RM Lechan and RJ Koenig
Division of Endocrinology, University of Michigan Medical Center, Ann Arbor 48109-0678.

A polymerase chain reaction based assay was used to evaluate expression of thyroid hormone receptor beta 2 mRNA in rat hypothalamus. Expression was detected in the arcuate, ventromedial and paraventricular nuclei, as well as the median eminence. Trace expression was found in the dorsomedial nucleus, but no expression of thyroid hormone receptor beta 2 was detected in the lateral hypothalamus or the preoptic region. The results indicate that, contrary to previous belief, expression of thyroid hormone receptor beta 2 is not confined to the anterior pituitary.


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