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Endocrinology, Vol 130, 678-684, Copyright © 1992 by Endocrine Society

ARTICLES

Modulation of kidney function in conscious Pekin ducks by atrial natriuretic factor

H Schutz, DA Gray and R Gerstberger
Max Planck Institute for Physiological and Clinical Research, W. G. Kerckhoff Institute, Bad Nauheim, Germany.

The influence of avian atrial natriuretic factor (ANF) on renal function was examined in conscious saltwater-acclimated Pekin ducks undergoing a steady state diuresis maintained by iv infused isotonic avian Krebs-Ringer solution at a rate of 1.0 ml/min. Synthetic chicken ANF (chANF) was applied iv at doses of 10, 50, and 90 ng/min.kg BW for 10 min and caused dose-dependent transient increases in urine flow, osmolal excretion, glomerular filtration rate, effective renal plasma flow, and fractional water clearance at decreased urinary osmolality. Using receptor autoradiography, binding sites for [125I]Bolton-Hunter- labeled chANF [( 125I]BH-chANF) were localized in both the reptilian- type glomeruli and the collecting duct system throughout the duck kidney. A RRA for [125I]BH-chANF, established using an enriched kidney membrane fraction, indicated that unlabeled chANF and human ANF competitively displaced [125I]BH-chANF with comparable potencies. ANF- induced modulation of renal salt and water elimination via glomerular and tubular receptor interactions is consistent with the concept that this hormone has a physiological role in avian volume homeostasis.


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