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Endocrinology, Vol 130, 1744-1746, Copyright © 1992 by Endocrine Society

ARTICLES

Expression of messenger RNA for insulin-like growth factors and insulin- like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo

A Manni, L Wei, B Badger, A Zaenglein, J Leighton, S Shimasaki and N Ling
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

We report the expression of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) by breast cancer cells and normal breast tissue in vivo. N-nitrosomethyl-urea (NMU)-induced rat mammary tumors synthesize mRNAs for IGF-II and IGFBP-2, -3, and -4. In contrast, normal lactating breast contains only IGFBP-2 and IGF-II messages; IGFBP-3 and -4 mRNAs are absent in this tissue. IGF-I and IGFBP-1 mRNAs are not expressed in either NMU tumors or in normal breast. This is the first report of in vivo expression of IGFBPs and IGF-II messages in breast tumors.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1992 by The Endocrine Society