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Endocrinology, Vol 131, 536-538, Copyright © 1992 by Endocrine Society

ARTICLES

Transgenic female mice with high human growth hormone levels are fertile and capable of normal lactation without having been pregnant

S Milton, M Cecim, YS Li, JS Yun, TE Wagner and A Bartke
Department of Physiology, Southern Illinois University, School of Medicine, Carbondale 62901.

Transgenic mice carrying the phosphoenolpyruvate carboxykinase promoter region-human growth hormone (PEPCK-hGH) fusion gene are characterized by accelerated growth and plasma hGH levels ranging from 100 to 700 ng/ml. Both sexes are fertile, in contrast to previous findings in metallothionein-I/hGH transgenic mice in which females are sterile, apparently due to luteal failure. Virgin transgenic PEPCK/hGH females from this line produce milk and can successfully raise foster litters to weaning. We conclude that the life-long presence of very large amounts of hGH in the circulation is compatible with ovulation, can override the effects of hGH-induced suppression of endogenous PRL release, and can support full lactation in animals that have not been primed by hormonal changes associated with pregnancy.


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