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Endocrinology, Vol 131, 2482-2484, Copyright © 1992 by Endocrine Society

ARTICLES

Vitamin E protects hypothalamic beta-endorphin neurons from estradiol neurotoxicity

GC Desjardins, A Beaudet, HM Schipper and JR Brawer
Department of Anatomy, McGill University, Montreal, Quebec.

Estradiol valerate (EV) treatment has been shown to result in the destruction of 60% of beta-endorphin neurons in the hypothalamic arcuate nucleus. Evidence suggests that the mechanism of EV-induced neurotoxicity involves the conversion of estradiol to catechol estrogen and subsequent oxidation to free radicals in local peroxidase-positive astrocytes. In this study, we examined whether treatment with the antioxidant, vitamin E, protects beta-endorphin neurons from the neurotoxic action of estradiol. Our results demonstrate that chronic vitamin E treatment prevents the decrement in hypothalamic beta- endorphin concentrations resulting from arcuate beta-endorphin cell loss, suggesting that the latter is mediated by free radicals. Vitamin E treatment also prevented the onset of persistent vaginal cornification and polycystic ovarian condition which have been shown to result from the EV-induced hypothalamic pathology.


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Copyright © 1992 by The Endocrine Society