help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brannstrom, M.
Right arrow Articles by Norman, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brannstrom, M.
Right arrow Articles by Norman, R. J.

Endocrinology, Vol 132, 399-404, Copyright © 1993 by Endocrine Society

ARTICLES

Ovulatory effect of interleukin-1 beta on the perfused rat ovary

M Brannstrom, L Wang and RJ Norman
Department of Obstetrics and Gynecology, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia.

The involvement of cytokines derived from ovarian and hematopoietic cells have been suggested in the cyclic events of the ovary. In the present study the effects of two cytokines, interleukin-1 beta (IL-1 beta) and IL-2, on ovulation, steroidogenesis, and prostaglandin (PG) production were explored in rat ovaries perfused in vitro. Ovaries of equine CG (20 IU)-primed immature rats were perfused in a recirculating system for 20 h, and samples were taken for analysis of progesterone, estradiol, prostaglandin E (PGE), and PGF2 alpha. The number of ovulations was estimated by counting the number of oocytes released into the ovarian bursae. Unstimulated ovaries did not ovulate, whereas the addition of LH (100 ng/ml) resulted in 3.4 +/- 0.6 ovulations/treated ovary. The addition of human recombinant IL-1 beta (4 ng/ml) induced ovulation (1.6 +/- 0.4) and increased the LH-induced ovulation rate 3-fold (9.8 +/- 0.5). The addition of human recombinant IL-2 (40 ng/ml) did not induce ovulation and did not affect the LH- induced ovulation rate. Ovarian release of progesterone and PGF2 alpha was increased by IL-1 beta, but estradiol and PGE release was not affected. IL-2 did not affect steroidogenesis or PG release. To elucidate whether the IL-1 beta-stimulated ovarian synthesis of PGF2 alpha was crucial for the ovulatory effect of IL-1 beta, experiments were performed in the presence of indomethacin (5 micrograms/ml), an inhibitor of PG synthesis. Indomethacin (5 micrograms/ml) inhibited LH- induced ovulation almost completely (one ovulation in one of the five treated ovaries), but did not affect the IL-1 beta-induced ovulation rate (1.4 +/- 0.2). The number of ovulations in the group treated with LH and IL-1 beta was significantly reduced (3.2 +/- 0.6) in the presence of indomethacin. These data demonstrate that IL-1 beta induces ovulation in the rat ovary, and this effect may be partly mediated by the increased production of the ovulatory mediator progesterone.


This article has been cited by other articles:


Home page
 Hum ReprodHome page
P. Dahm-Kahler, C. Lofman, R. Fujii, M. Axelsson, P. O. Janson, and M. Brannstrom
An intravital microscopy method permitting continuous long-term observations of ovulation in vivo in the rabbit
Hum. Reprod., March 1, 2006; 21(3): 624 - 631.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Sayasith, N. Bouchard, D. Boerboom, K. A. Brown, M. Dore, and J. Sirois
Molecular Characterization of Equine P-Selectin (CD62P) and Its Regulation in Ovarian Follicles During the Ovulatory Process
Biol Reprod, March 1, 2005; 72(3): 736 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Bonello, M. J. Jasper, and R. J. Norman
Periovulatory Expression of Intercellular Adhesion Molecule-1 in the Rat Ovary
Biol Reprod, October 1, 2004; 71(4): 1384 - 1390.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. M. Mitchell, C.R. Kennedy, and G. M. Hartshorne
Pharmacological manipulation of nitric oxide levels in mouse follicle cultures demonstrates key role of extrafollicular control of ovulation
Hum. Reprod., August 1, 2004; 19(8): 1705 - 1712.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
R. Wu, K. H. Van der Hoek, N. K. Ryan, R. J. Norman, and R. L. Robker
Macrophage contributions to ovarian function
Hum. Reprod. Update, March 1, 2004; 10(2): 119 - 133.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. E. Curry Jr. and K. G. Osteen
The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle
Endocr. Rev., August 1, 2003; 24(4): 428 - 465.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Martoriati, G. Duchamp, and N. Gerard
In Vivo Effect of Epidermal Growth Factor, Interleukin-1{beta}, and Interleukin-1RA on Equine Preovulatory Follicles
Biol Reprod, May 1, 2003; 68(5): 1748 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Yanagi, S. Makinoda, R. Fujii, S. Miyazaki, S. Fujita, H. Tomizawa, K. Yoshida, T. Iura, T. Takegami, and T. Nojima
Cyclic changes of granulocyte colony-stimulating factor (G-CSF) mRNA in the human follicle during the normal menstrual cycle and immunolocalization of G-CSF protein
Hum. Reprod., December 1, 2002; 17(12): 3046 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Martoriati, A.-C. Lalmanach, G. Goudet, and N. Gerard
Expression of Interleukin-1 (IL-1) System Genes in Equine Cumulus-Oocyte Complexes and Influence of IL-1{beta} During In Vitro Maturation
Biol Reprod, August 1, 2002; 67(2): 630 - 636.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Saito, M. Ando, D. Sussman, H. Negishi, G. King, and E. Y. Adashi
Interleukin 1 Upregulates Ovarian Prostaglandin Endoperoxide Synthase-2 Expression: Evidence for Prostaglandin-Dependent/Ceramide-Independent Transcriptional Stimulation and for Message Stabilization
Biol Reprod, December 1, 2001; 65(6): 1759 - 1765.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. H. Kodaman and H. R. Behrman
Endocrine-Regulated and Protein Kinase C-Dependent Generation of Superoxide by Rat Preovulatory Follicles
Endocrinology, February 1, 2001; 142(2): 687 - 693.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Runesson, K. Ivarsson, P. Olof Janson, and M. Brännström
Gonadotropin- and Cytokine-Regulated Expression of the Chemokine Interleukin 8 in the Human Preovulatory Follicle of the Menstrual Cycle
J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4387 - 4395.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
K. W. Chung, M. Ando, and E. Y. Adashi
Periovulatory and Interleukin (IL)-1--Dependent Reglation of IL-6 in the Immature Rat Ovary: A Specific IL-1 Receptor-Mediated Eicosanoid-Dependent Effect
Reproductive Sciences, September 1, 2000; 7(5): 301 - 308.
[Abstract] [PDF]

Home page
 Biol. Reprod.Home page
K.H. Van der Hoek, S. Maddocks, C.M. Woodhouse, N. van Rooijen, S.A. Robertson, and R.J. Norman
Intrabursal Injection of Clodronate Liposomes Causes Macrophage Depletion and Inhibits Ovulation in the Mouse Ovary
Biol Reprod, April 1, 2000; 62(4): 1059 - 1066.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
E. Levitas, D. Chamoun, L. C. Udoff, M. Ando, C. E. Resnick, and E. Y. Adashi
Periovulatory and Interleukin-1{beta}-Dependent Up-Regulation of Intraovarian Vascular Endothelial Growth Factor (VEGF) in the Rat: Potential Role for VEGF in the Promotion of Periovulatory Angiogenesis and Vascular Permeability
Reproductive Sciences, January 1, 2000; 7(1): 51 - 60.
[Abstract] [PDF]

Home page
 Biol. Reprod.Home page
H. Bagavant, S. Adams, P. Terranova, A. Chang, F. W. Kraemer, Y. Lou, K. Kasai, A. M. Luo, and K. S.K. Tung
Autoimmune Ovarian Inflammation Triggered by Proinflammatory (Th1) T Cells Is Compatible with Normal Ovarian Function in Mice
Biol Reprod, September 1, 1999; 61(3): 635 - 642.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. Chamoun, M. D. DeMoura, E. Levitas, C. E. Resnick, S. E. Gargosky, R. G. Rosenfeld, T. Matsumoto, and E. Y. Adashi
Transcriptional and Posttranscriptional Regulation of Intraovarian Insulin-Like Growth Factor-Binding Proteins by Interleukin-1{beta} (IL-1{beta}): Evidence for IL-1{beta} as an Antiatretic Principal
Endocrinology, August 1, 1999; 140(8): 3488 - 3495.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
S. Kol, B. W. Donesky, K. Ruutiainen-Altman, I. Ben-Shlomo, M. Irahara, M. Ando, R. M. Rohan, and E. Y. Adashi
Ovarian Interleukin-1 Receptor Antagonist in Rats: Gene Expression, Cellular Localization, Cyclic Variation, and Hormonal Regulation of a Potential Determinant of Interleukin-1 Action
Biol Reprod, July 1, 1999; 61(1): 274 - 282.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. J. Davis, D. E. Lennard, C. A. Lee, H. F. Tiano, S. G. Morham, W. C. Wetsel, and R. Langenbach
Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1{beta}
Endocrinology, June 1, 1999; 140(6): 2685 - 2695.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
B. Shinetugs, E. Runesson, N.P. Bonello, M. Brannstrom, and R.J. Norman
Colony stimulating factor-1 concentrations in blood and follicular fluid during the human menstrual cycle and ovarian stimulation: possible role in the ovulatory process
Hum. Reprod., May 1, 1999; 14(5): 1302 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Irahara, M. Ando, J. Sirois, J. Saito, and E. Y. Adashi
Glucocorticoid Receptor-Mediated Post-Ceramide Inhibition of the Interleukin-1ß-Dependent Induction of Ovarian Prostaglandin Endoperoxide Synthase-2 in Rats
Biol Reprod, April 1, 1999; 60(4): 946 - 953.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
S.-i. Wada, T. Kudo, M. Kudo, N. Sakuragi, H. Hareyama, J. Nishihira, and S. Fujimoto
Induction of macrophage migration inhibitory factor in human ovary by human chorionic gonadotrophin
Hum. Reprod., February 1, 1999; 14(2): 395 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. J. Acosta, A. Miyamoto, T. Ozawa, M. P.B. Wijayagunawardane, and K. Sato
Local Release of Steroid Hormones, Prostaglandin E2, and Endothelin-1 from Bovine Mature Follicles In Vitro: Effects of Luteinizing Hormone, Endothelin-1, and Cytokines
Biol Reprod, August 1, 1998; 59(2): 437 - 443.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. Ando, S. Kol, E. Kokia, K. Ruutiainen-Altman, J. Sirois, R. M. Rohan, D. W. Payne, and E. Y. Adashi
Rat Ovarian Prostaglandin Endoperoxide Synthase-1 and -2: Periovulatory Expression of Granulosa Cell-Based Interleukin-1-Dependent Enzymes
Endocrinology, May 1, 1998; 139(5): 2501 - 2508.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Narko, O. Ritvos, and A. Ristimaki
Induction of Cyclooxygenase-2 and Prostaglandin F2{alpha} Receptor Expression by Interleukin-1{beta} in Cultured Human Granulosa-Luteal Cells
Endocrinology, September 1, 1997; 138(9): 3638 - 3644.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. Ben-Shlomo, S. Kol, L. M. Roeder, C. E. Resnick, A. Hurwitz, D. W. Payne, and E. Y. Adashi
Interleukin (IL)-1{beta} Increases Glucose Uptake and Induces Glycolysis in Aerobically Cultured Rat Ovarian Cells: Evidence That IL-1{beta} May Mediate the Gonadotropin-Induced Midcycle Metabolic Shift
Endocrinology, July 1, 1997; 138(7): 2680 - 2688.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Kol, I. Ben-Shlomo, M. Ando, D. W. Payne, and E. Y. Adashi
Interleukin-1{beta} Stimulates Ovarian Phospholipase A2 (PLA2) Expression and Activity: Up-Regulation of Both Secretory and Cytosolic PLA2
Endocrinology, January 1, 1997; 138(1): 314 - 321.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Kol, K. Ruutiainen-Altman, I. Ben-Shlomo, D. W. Payne, M. Ando, and E. Y. Adashi
The Rat Ovarian Phospholipase A2 System: Gene Expression, Cellular Localization, Activity Characterization, and Interleukin-1 Dependence
Endocrinology, January 1, 1997; 138(1): 322 - 331.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
W. J. Scherzer, K. S. L. Ruutiainen-Altman, L. T. Putowski, S. Kol, E. Y. Adashi, and R. M. Rohan
Detection and In Vivo Hormonal Regulation of Rat Ovarian Type I and Type II Interleukin-I Rececptor mRNAs: Increased Expression During the Periovulatory Period
Reproductive Sciences, May 1, 1996; 3(3): 131 - 139.
[Abstract] [PDF]

Home page
 Reproductive SciencesHome page
A. Hurwitz, Z. Finci-Yeheskel, M. Dushnik, A. Milwidsky, S. Shimonovitz, S. Yagel, E. Y. Adashi, and M. Mayer
Interleukin-1-Mediated Regulation of Plasminogen Activation in Pregnant Mare Serum Gonadotropin-Primed Rat Granulosa Cells Is Independent of Prostaglandin Production
Reproductive Sciences, September 1, 1995; 2(5): 691 - 699.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1993 by The Endocrine Society