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Endocrinology, Vol 132, 1603-1608, Copyright © 1993 by Endocrine Society

ARTICLES

Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells

M Iwasaki, K Nakata, H Nakahara, T Nakase, T Kimura, K Kimata, AI Caplan and K Ono
Department of Orthopaedic Surgery, Osaka University Medical School, Japan.

Chick periosteum-derived mesenchymal cells have been reported to exhibit both osteogenic and chondrogenic potentials in high cell density culture conditions. Using this culture system, the effects of transforming growth factor-beta (TGF beta) on proliferation and differentiation of periosteal mesenchymal cells were studied. Supplementation with TGF beta 1 at doses of 0.3-1.0 ng/ml shortened the time course of chondrogenesis and increased the amount of cartilage formed in the lower part of the culture. On the other hand, the amount of bone formed in the upper part of the culture decreased with TGF beta treatment, whereas the time course of osteogenesis remained unaffected.


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