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Endocrinology, Vol 132, 2484-2490, Copyright © 1993 by Endocrine Society

ARTICLES

Identification and expression of G-proteins in human myometrium: up- regulation of G alpha s in pregnancy

GN Europe-Finner, S Phaneuf, SP Watson and A Lopez Bernal
University of Oxford, Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Headington, United Kingdom.

We report that human myometrium contains G alpha i1, G alpha i3, and G alpha q, and G alpha 11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. G alpha i2 is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in G alpha s expression in pregnant myometrium. The increase in G alpha s levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.


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