| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Endocrinology, Vol 133, 511-514, Copyright © 1993 by Endocrine Society
ARTICLES |
G Neri, LK Malendowicz, P Andreis and GG Nussdorfer
Department of Anatomy, University of Padua, Italy.
The bolus iv administration of TRH dose-dependently decreased ACTH- enhanced plasma corticosterone (B) concentration in rats, without affecting the basal one. The effects of TRH on steroid secretion of dispersed rat inner adrenocortical cells were investigated by HPLC. TRH significantly decreased both basal and ACTH-stimulated post-11- deoxycorticosterone (DOC) secretion (i.e. 18-hydroxy-DOC and B) and concomitantly raised DOC and progesterone release, so that the total postpregnenolone yield of our preparations was unaffected. TRH did not alter either basal or ACTH-stimulated pregnenolone production by isolated rat adrenocortical cells. It was concluded that TRH is an inhibitor of glucocorticoid secretion in rats, which electively impairs the late steps of B synthesis (i.e. 11- and 18-hydroxylation) without affecting the earlier steps, including the rate-limiting one of this process.
This article has been cited by other articles:
 |
|
 |
|
  G. Neri, S. Bova, L. K. Malendowicz, G. Mazzocchi, and G. G. Nussdorfer Simulated microgravity impairs aldosterone secretion in rats: possible involvement of adrenomedullin Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R832 - R836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Malendowicz, M. Nowak, L. Gottardo, C. Tortorella, M. Majchrzak, and G. G. Nussdorfer Cholecystokinin Stimulates Aldosterone Secretion from Dispersed Rat Zona Glomerulosa Cells, Acting Through Cholecystokinin Receptors 1 and 2 Coupled with the Adenylate Cyclase-Dependent Cascade Endocrinology, October 1, 2001; 142(10): 4251 - 4255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Mazzocchi, L. K. Malendowicz, A. Markowska, G. Albertin, and G. G. Nussdorfer Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1027 - E1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Lo, M.-M. Kau, Y.-H. Chen, S.-C. Tsai, Y.-C. Chiao, J.-J. Chen, C. Liaw, C.-C. Lu, B.-P. Lee, S.-C. Chen, et al. Acute effects of thyroid hormones on the production of adrenal cAMP and corticosterone in male rats Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E238 - E245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. P. Rossi, G. Albertin, G. Neri, P. G. Andreis, S. Hofmann, A. C. Pessina, and G. G. Nussdorfer Endothelin-1 Stimulates Steroid Secretion of Human Adrenocortical Cells ex Vivo Via Both ETA and ETB Receptor Subtypes J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3445 - 3449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Klootwijk, E. Sleddens-Linkels, R. D. H. de Boer, C. A. Jansen, R. Autar, W. W. de Herder, E.R. Boeve, T. J. Visser, and W. J. de Greef Renal Clearance of the Thyrotropin-Releasing Hormone-Like Peptide Pyroglutamyl-Glutamyl-Prolineamide in Humans J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3068 - 3073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Belloni, G. P. Rossi, P. G. Andreis, G. Neri, G. Albertin, A. C. Pessina, and G. G. Nussdorfer Endothelin Adrenocortical Secretagogue Effect Is Mediated by the B Receptor in Rats Hypertension, May 1, 1996; 27(5): 1153 - 1159. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
