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Endocrinology, Vol 134, 264-270, Copyright © 1994 by Endocrine Society

ARTICLES

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance

C Hofmann, K Lorenz, SS Braithwaite, JR Colca, BJ Palazuk, GS Hotamisligil and BM Spiegelman
Research Service, Hines Veterans Administration Hospital, Illinois 60141.

As obesity is a major risk factor for noninsulin-dependent diabetes mellitus, adipose tissue may generate a mediator that influences the activity of insulin on various target tissues. Recent evidence suggests that a cytokine, tumor necrosis factor-alpha (TNF alpha), may serve this role. This study investigates whether the expression of TNF alpha and its receptors is modulated during drug treatment to reduce insulin resistance. The effects of moderate weight loss by dietary restriction were also examined. We show here that a marked induction of TNF alpha mRNA occurs in adipose tissues from a mouse model of obesity-linked diabetes (KKAy) compared to that in nondiabetic mice (C57). Likewise, RNA transcripts encoding TNF R2 receptors (p75) were significantly increased in fat tissues of the obese diabetic animals. In muscle from these diabetic animals, RNA transcripts encoding both TNF R1 (p55) and R2 were significantly elevated, although R2 transcript abundance was less elevated than in fat. We also observed that the overexpression of mRNA for TNF alpha and both of its receptors could be at least partly normalized by treatment of the diabetic animals with the insulin- sensitizing agent pioglitazone. Treating of the obese diabetic animals by food restriction reduced the expression of mRNA for TNF R2 in muscle, but not fat. These results clearly indicate that gene expression for the TNF systems can be regulated by an insulin- sensitizing drug and reduction of body weight. Such findings support a role for this cytokine in the insulin-resistant diabetic state and show its modulation by therapies that reverse the disorder.


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[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
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Endocr. Rev., December 1, 2000; 21(6): 585 - 618.
[Abstract] [Full Text]

Home page
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[Abstract] [Full Text]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E196 - E205.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 530 - 535.
[Abstract] [Full Text]

Home page
 Exp. Biol. Med.Home page
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Experimental Biology and Medicine, February 1, 2000; 223(2): 128 - 135.
[Abstract] [Full Text]

Home page
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Biol Reprod, October 1, 1999; 61(4): 993 - 998.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., September 10, 1999; 274(37): 26287 - 26295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Raina, J. Lamarre, C.-C. Liew, A. H. Lofti, and K. N. Jeejeebhoy
Effect of nutrition on tumor necrosis factor receptors in weight-gaining and -losing rats
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E464 - E473.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
U. Edvardsson, M. Bergström, M. Alexandersson, K. Bamberg, B. Ljung, and B. Dahllöf
Rosiglitazone (BRL49653), a PPAR{gamma}-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
J. Lipid Res., July 1, 1999; 40(7): 1177 - 1184.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Samad, K. T. Uysal, S. M. Wiesbrock, M. Pandey, G. S. Hotamisligil, and D. J. Loskutoff
Tumor necrosis factor alpha  is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1
PNAS, June 8, 1999; 96(12): 6902 - 6907.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Iwata, S. Sato, J. Jimenez, M. McGowan, M. Moroni, A. Dey, N. Ibaraki, V. N. Reddy, and D. Carper
Osmotic Response Element Is Required for the Induction of Aldose Reductase by Tumor Necrosis Factor-alpha
J. Biol. Chem., March 19, 1999; 274(12): 7993 - 8001.
[Abstract] [Full Text] [PDF]

Home page
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Endocrinology, December 1, 1998; 139(12): 4832 - 4838.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor-{alpha} (TNF-{alpha})-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-{alpha}
Endocrinology, December 1, 1998; 139(12): 4928 - 4935.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Endocrinol., August 1, 1998; 12(8): 1150 - 1160.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Paolisso, M. R. Rizzo, G. Mazziotti, M. R. Tagliamonte, A. Gambardella, M. Rotondi, C. Carella, D. Giugliano, M. Varricchio, and F. D'Onofrio
Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha
Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E294 - E299.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Assuma, T. Oates, D. Cochran, S. Amar, and D. T. Graves
IL-1 and TNF Antagonists Inhibit the Inflammatory Response and Bone Loss in Experimental Periodontitis
J. Immunol., January 1, 1998; 160(1): 403 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. A. Hansen, D. H. Han, L. A. Nolte, M. Chen, and J. O. Holloszy
DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1704 - R1708.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. E. Hadri, A. Courtalon, X. Gauthereau, A.-M. Chambaut-Guerin, J. Pairault, and B. Feve
Differential Regulation by Tumor Necrosis Factor-alpha of beta 1-, beta 2-, and beta 3-Adrenoreceptor Gene Expression in 3T3-F442A Adipocytes
J. Biol. Chem., September 26, 1997; 272(39): 24514 - 24521.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Furnsinn, S. Neschen, O. Wagner, M. Roden, M. Bisschop, and W. Waldhausl
Acute and Chronic Exposure to Tumor Necrosis Factor-{alpha} Fails to Affect Insulin-Stimulated Glucose Metabolism of Isolated Rat Soleus Muscle
Endocrinology, July 1, 1997; 138(7): 2674 - 2679.
[Abstract] [Full Text] [PDF]

Home page
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Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein
Science, November 22, 1996; 274(5291): 1377 - 1379.
[Abstract] [Full Text]

Home page
 NEJMHome page
F. Bazzoni and B. Beutler
The Tumor Necrosis Factor Ligand and Receptor Families
N. Engl. J. Med., June 27, 1996; 334(26): 1717 - 1725.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Peraldi, G. S. Hotamisligil, W. A. Buurman, M. F. White, and B. M. Spiegelman
Tumor Necrosis Factor (TNF)-alpha Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase
J. Biol. Chem., May 31, 1996; 271(22): 13018 - 13022.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.