Endocrinology, Vol 134, 271-276, Copyright © 1994 by Endocrine Society

ARTICLES

Regulation of c-fos expression in adipose and muscle tissue of diabetic rats

AL Olson and JE Pessin
Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City 52242.

Insulin treatment of control rats demonstrated a marked 8-fold transient increase (15 min) in c-fos mRNA in white adipose tissue, which returns to basal levels by 5 h. Similarly, insulin treatment resulted in a rapid 9-fold increase in cardiac muscle c-fos mRNA, which also returned to control values by 1 h. By contrast, insulin treatment resulted in only a small increase in c-jun mRNA levels in both adipose tissue and cardiac muscle. Similarly, the expression of c-jun mRNA was only slightly responsive to insulin in these tissues from streptozocin- induced insulin-deficient diabetic rats. However, insulin treatment of insulin-deficient diabetic rats resulted in a prolonged increase in c- fos message levels in adipose tissue without any significant change in the time course of c-fos mRNA induction/repression in cardiac muscle. These data demonstrate that in contrast to c-jun, c-fos is transiently increased in both cardiac muscle and adipose tissue by insulin treatment. Furthermore, transrepression of the c-fos gene is specifically attenuated in adipose tissue of insulin-deficient diabetic rats, but not in cardiac muscle.

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