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Endocrinology, Vol 135, 175-182, Copyright © 1994 by Endocrine Society

ARTICLES

Environmentally persistent alkylphenolic compounds are estrogenic

R White, S Jobling, SA Hoare, JP Sumpter and MG Parker
Laboratory of Molecular Endocrinology, Imperial Cancer Research Fund, London, United Kingdom.

We show that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals. 4-Octylphenol (OP), 4-nonylphenol, 4- nonylphenoxycarboxylic acid, and 4-nonylphenoldiethoxylate were each capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines. The most potent of the chemicals is OP, which was able to stimulate these biological responses to a similar extent as 17 beta-estradiol itself, albeit at a 1000-fold greater concentration. The action of alkylphenols is mediated by the estrogen receptor, as their effects depended on its presence and was blocked by estrogen antagonists. OP, 4-nonylphenol, and 4-nonylphenoxycarboxylic acid appear to possess intrinsic estrogenic activity, because they compete for binding to the estrogen receptor. Moreover, it is likely that they interact with a similar region of the hormone-binding domain as 17 beta- estradiol, because the mutant receptor G-525R, which is defective in estrogen binding, is also insensitive to OP. Like 17 beta-estradiol, OP is capable of stimulating the activity of both transcriptional activation functions, TAF-1 and TAF-2, in the receptor, as judged by analyzing the activity of the wild-type and mutant receptors in transiently transfected cells. The significance of our results will depend to a large extent on the degree of exposure of wildlife and humans to these estrogenic alkylphenolic compounds.


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[Abstract] [Full Text] [PDF]

Home page
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Toxicol. Sci., August 1, 2001; 62(2): 257 - 267.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text]

Home page
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Toxicol. Sci., March 1, 2001; 60(1): 56 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
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[Abstract] [Full Text]

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[Abstract] [PDF]

Home page
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Effect of 4-octylphenol on germ cell number in cultured human fetal gonads
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Endocrinology, July 1, 2000; 141(7): 2667 - 2673.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
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Experimental Biology and Medicine, June 1, 2000; 224(2): 61 - 68.
[Abstract] [Full Text]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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A Rapid and Sensitive Reporter Gene that Uses Green Fluorescent Protein Expression to Detect Chemicals with Estrogenic Activity
Toxicol. Sci., May 1, 2000; 55(1): 69 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
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Toxicol. Sci., March 1, 2000; 54(1): 138 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
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Effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in male platyfish Xiphophorus maculatus
J. Exp. Biol., January 1, 2000; 203(2): 171 - 181.
[Abstract] [PDF]

Home page
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Variations of Light and Temperature Regimes and Resulting Effects on Reproductive Parameters in Medaka (Oryzias latipes)
Biol Reprod, November 1, 1999; 61(5): 1287 - 1293.
[Abstract] [Full Text]

Home page
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Toxicology and Industrial Health, February 1, 1999; 15(1-2): 12 - 25.
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Home page
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Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor {beta}
Endocrinology, October 1, 1998; 139(10): 4252 - 4263.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
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J. Bacteriol., September 1, 1998; 180(17): 4332 - 4338.
[Abstract] [Full Text]

Home page
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J. I. Macgregor and V. C. Jordan
Basic Guide to the Mechanisms of Antiestrogen Action
Pharmacol. Rev., June 1, 1998; 50(2): 151 - 196.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. O. Ruehlmann, J. R. Steinert, M. A. Valverde, R. Jacob, and G. E. Mann
Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells
FASEB J, May 1, 1998; 12(7): 613 - 619.
[Abstract] [Full Text]

Home page
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N. G. Coldham, S. Sivapathasundaram, M. Dave, L. A. Ashfield, T. G. Pottinger, C. Goodall, and M. J. Sauer
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Drug Metab. Dispos., April 1, 1998; 26(4): 347 - 354.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child.Home page
B A J Evans, I A Hughes, C L Bevan, M N Patterson, and J W Gregory
Phenotypic diversity in siblings with partial androgen insensitivity syndrome
Arch. Dis. Child., June 1, 1997; 76(6): 529 - 531.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
K. Ramamoorthy, F. Wang, I-C. Chen, J. D. Norris, D. P. McDonnell, L. S. Leonard, K. W. Gaido, W. P. Bocchinfuso, K. S. Korach, and S. Safe
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Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., February 7, 1997; 272(6): 3280 - 3288.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Cross, Z Werb, and S. Fisher
Implantation and the placenta: key pieces of the development puzzle
Science, December 2, 1994; 266(5190): 1508 - 1518.
[Abstract] [PDF]

Home page
 BMJHome page
N E Skakkebaek and N Keiding
Changes in semen and the testis
BMJ, November 19, 1994; 309(6965): 1316 - 1317.