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Endocrinology, Vol 135, 662-666, Copyright © 1994 by Endocrine Society

ARTICLES

Leydig tumor cell protein phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor is identified as stathmin

SR Hoelscher and M Ascoli
Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242.

Although hCG and mouse epidermal growth factor activate different signaling systems in a clonal strain of Leydig tumor cells (designated MA-10), both compounds are capable of increasing steroidogenesis, decreasing transcription of the LH/CG receptor gene, and attenuating adenylyl cyclase. We have recently identified a 21-kilodalton protein (p21) that is a potential intermediary in the actions of mouse epidermal growth factor and hCG. Characterization of p21 revealed similarities to stathmin, a ubiquitous phosphoprotein whose phosphorylation is associated with diverse second messenger pathways. Using two different experimental approaches, Western blotting and immunoprecipitation, we present data that identify p21 as stathmin.


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