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Endocrinology, Vol 136, 2427-2434, Copyright © 1995 by Endocrine Society

ARTICLES

Modulation of vascular natriuretic peptide receptor gene expression in hypertensive and obese hyperglycemic rats

T Yoshimoto, M Naruse, K Naruse, Y Fujimaki, A Tanabe, T Muraki, M Itakura, H Hagiwara, S Hirose and H Demura
Department of Medicine, Tokyo Women's Medical College, Japan.

Receptors for natriuretic peptide (NP) consist of three subtypes: NP-A, NP-B, and NP-C. Recent studies in cultured aortic cells have suggested a phenotype-related switching of the vascular NP receptor from NP-A to NP-B. To ascertain the biological significance of the phenomenon in vivo, we developed a sensitive and reproducible ribonuclease protection assay and determined each receptor messenger RNA (mRNA) level in the vascular vessels of stroke-prone spontaneously hypertensive rats, deoxycorticosterone acetate-salt hypertensive rats, and genetically hyperglycemic. Wistar fatty rats and in cultured aortic smooth muscle cells. The aortic NP-A receptor mRNA level was significantly up- regulated in both types of hypertensive rats, whereas the NP-B receptor mRNA level did not show any significant change. Both NP-A and NP-B receptor mRNA levels were significantly up-regulated in Wistar fatty rats compared with the control values. There was no significant up- regulation of NP-A receptor mRNA in the inferior vena cava of the stroke-prone spontaneously hypertensive rats. Although the NP-A receptor was always the predominant subtype in rat aortic tissue, NP-B receptor was the predominant subtype in aortic smooth muscle cells in culture. These findings suggest that up-regulation of the NP-A receptor, but not the subtype switching, is the major modulation of receptor gene expression in both hypertensive and diabetic rats.


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T. Yoshimoto, M. Naruse, A. Tanabe, K. Naruse, T. Seki, T. Imaki, T. Muraki, Y. Matsuda, and H. Demura
Potentiation of Natriuretic Peptide Action by the {beta}-Adrenergic Blocker Carvedilol in Hypertensive Rats: A New Antihypertensive Mechanism
Endocrinology, January 1, 1998; 139(1): 81 - 88.
[Abstract] [Full Text] [PDF]


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