Endocrinology, Vol 136, 3936-3941, Copyright © 1995 by Endocrine Society

ARTICLES

Inhibitory effects of interleukin-1 on growth hormone secretion in conscious male rats

Y Wada, M Sato, M Niimi, M Tamaki, T Ishida and J Takahara
First Department of Internal Medicine, Kagawa Medical School, Japan.

Although various pathophysiological effects of interleukin (IL) on the CRF-ACTH-adrenal axis and gonadotropin secretion have been studied extensively, the effects of IL on GH secretion still remain to be elucidated. We investigated the possible effects of IL on GH secretion in six groups of conscious rats. In four groups, IL was administered by continuous iv infusion and in the other two, by intracerebroventricular injection. Saline-treated rats served as controls for these groups. Sequential blood sampling was performed every 20 min in all groups, and the plasma GH concentration was determined by RIA. The expression of hypothalamic c-fos protein in a separate group was examined by immunohistochemistry. Continuous infusion of both IL-1 alpha and IL-1 beta (10 ng/min) significantly inhibited GH surges. The plasma IL-1 level was elevated to 2-3 ng/ml. Continuous iv infusion of IL-2 and IL- 6 had no effect on GH secretion. The intracerebroventricular injection of both IL-1 alpha and IL-1 beta significantly inhibited GH surges, and the inhibitory effect was much greater for IL-1 beta than for IL-1 alpha. Continuous iv infusion of IL-1 beta markedly stimulated c-fos expression in specific hypothalamic nuclei, particularly in the paraventricular nucleus. These findings suggest that, in the rat, IL-1 inhibits GH secretion through its peripheral and central actions.

This article has been cited by other articles:

				P. W. Bodell, E. Kodesh, F. Haddad, F. P. Zaldivar, D. M. Cooper, and G. R. Adams Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise J Appl Physiol, February 1, 2009; 106(2): 443 - 453. [Abstract] [Full Text] [PDF]

				D. Nemet, A. Eliakim, F. Zaldivar, and D. M. Cooper Effect of rhIL-6 infusion on GH->IGF-I axis mediators in humans Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1663 - R1668. [Abstract] [Full Text] [PDF]

				Y. L. Liu, D. F. Li, L. M. Gong, G. F. Yi, A. M. Gaines, and J. A. Carroll Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge J Anim Sci, November 1, 2003; 81(11): 2758 - 2765. [Abstract] [Full Text] [PDF]

				D. Nemet, Y. Oh, H.-S. Kim, M. Hill, and D. M. Cooper Effect of Intense Exercise on Inflammatory Cytokines and Growth Mediators in Adolescent Boys Pediatrics, October 1, 2002; 110(4): 681 - 689. [Abstract] [Full Text] [PDF]

				P. TIRAKITSOONTORN, E. NUSSBAUM, C. MOSER, M. HILL, and D. M. COOPER Fitness, Acute Exercise, and Anabolic and Catabolic Mediators in Cystic Fibrosis Am. J. Respir. Crit. Care Med., October 15, 2001; 164(8): 1432 - 1437. [Abstract] [Full Text] [PDF]

				E. E. Muller, V. Locatelli, and D. Cocchi Neuroendocrine Control of Growth Hormone Secretion Physiol Rev, April 1, 1999; 79(2): 511 - 607. [Abstract] [Full Text] [PDF]

				J. Sauer, U. Renner, U. Hopfner, M. Lange, A. Müller, C. J. Strasburger, U. Pagotto, E. Arzt, and G. K. Stalla Interleukin-1{beta} Enhances Interleukin-1 Receptor Antagonist Content in Human Somatotroph Adenoma Cell Cultures J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2429 - 2434. [Abstract] [Full Text]

				C. H. Lang, J. Fan, M. M. Wojnar, T. C. Vary, and R. Cooney Role of central IL-1 in regulating peripheral IGF-I during endotoxemia and sepsis Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1998; 274(4): R956 - R962. [Abstract] [Full Text] [PDF]

				J.-P. Thissen and J. Verniers Inhibition by Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} of the Insulin-Like Growth Factor I Messenger Ribonucleic Acid Response to Growth Hormone in Rat Hepatocyte Primary Culture Endocrinology, March 1, 1997; 138(3): 1078 - 1084. [Abstract] [Full Text] [PDF]