help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sato, A.
Right arrow Articles by Funder, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sato, A.
Right arrow Articles by Funder, J. W.

Endocrinology, Vol 137, 4145-4153, Copyright © 1996 by Endocrine Society

ARTICLES

High glucose stimulates aldosterone-induced hypertrophy via type I mineralocorticoid receptors in neonatal rat cardiomyocytes

A Sato and JW Funder
Baker Medical Research Institute, Melbourne, Australia.

Previous studies have shown that aldosterone plus salt loading cause cardiac hypertrophy in rats in vivo, and that in vitro, both aldosterone and glucose stimulate fibroblast growth. The present studies examined the effects of adrenal steroids via mineralocorticoid and glucocorticoid receptors (MR and GR) on [3H]leucine incorporation by neonatal rat cardiomyocytes in culture and the role of elevated glucose in modulating such effects. GR occupancy by corticosterone, the highly selective type II (glucocorticoid) receptor agonist RU28362, or high doses of aldosterone lowers incorporation; when this effect is blocked by coincubation with the glucocorticoid antagonist RU486, aldosterone, but not corticosterone, markedly elevates leucine incorporation, indicating a specific mineralocorticoid effect via MR. Incubation with high glucose alone does not increase incorporation, but markedly increases the hypertropic effect of aldosterone in terms of both threshold and maximum response. The glucose-aldosterone synergy is via MR and is completely blocked by spironolactone. The time course of increased incorporation is identical for aldosterone acting alone or with elevated glucose, consistent with widespread transcriptional effects and suggesting that the contribution of high glucose is not rate limiting. The glucose effect reflects neither induction of MR synthesis nor an increase in their affinity; it is specific, in that it is not mimicked by L-glucose or mannitol at equal concentrations, and is mediated via an increase in protein kinase C activity that can be measured in both soluble and particulate compartments. The role of this synergy in the cardiac sequelae of diabetes remains to be explored.


This article has been cited by other articles:


Home page
 HypertensionHome page
A. S. Mihailidou, T. Y. Loan Le, M. Mardini, and J. W. Funder
Glucocorticoids Activate Cardiac Mineralocorticoid Receptors During Experimental Myocardial Infarction
Hypertension, December 1, 2009; 54(6): 1306 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
M. Minnaard-Huiban, J.J. R. Hermans, H. van Essen, N. Bitsch, and J. F.M. Smits
Comparison of the effects of intrapericardial and intravenous aldosterone infusions on left ventricular fibrosis in rats
Eur J Heart Fail, December 1, 2008; 10(12): 1166 - 1171.
[Abstract] [Full Text] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
Hari Krishnan Parthasarathy and T. Macdonald
Review: Aldosterone Antagonists
The British Journal of Diabetes & Vascular Disease, September 1, 2008; 8(5): 215 - 219.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
A. J. Rickard, J. W. Funder, J. Morgan, P. J. Fuller, and M. J. Young
Does Glucocorticoid Receptor Blockade Exacerbate Tissue Damage after Mineralocorticoid/Salt Administration?
Endocrinology, October 1, 2007; 148(10): 4829 - 4835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Ohtani, M. Ohta, K. Yamamoto, T. Mano, Y. Sakata, M. Nishio, Y. Takeda, J. Yoshida, T. Miwa, M. Okamoto, et al.
Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure: beneficial effects of mineralocorticoid receptor blocker
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R946 - R954.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Pchejetski, O. Kunduzova, A. Dayon, D. Calise, M.-H. Seguelas, N. Leducq, I. Seif, A. Parini, and O. Cuvillier
Oxidative Stress-Dependent Sphingosine Kinase-1 Inhibition Mediates Monoamine Oxidase A-Associated Cardiac Cell Apoptosis
Circ. Res., January 5, 2007; 100(1): 41 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Lister, D. J. Autelitano, A. Jenkins, R. D. Hannan, and K. E. Sheppard
Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1
Cardiovasc Res, June 1, 2006; 70(3): 555 - 565.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. J. Fuller and M. J. Young
Mechanisms of Mineralocorticoid Action
Hypertension, December 1, 2005; 46(6): 1227 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Karram, A. Abbasi, S. Keidar, E. Golomb, I. Hochberg, J. Winaver, A. Hoffman, and Z. Abassi
Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1351 - H1358.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
F. K Shieh, E. Kotlyar, and F. Sam
Aldosterone and cardiovascular remodelling: focus on myocardial failure
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2004; 5(1): 3 - 13.
[Abstract] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. H. Hostetter and H. N. Ibrahim
Aldosterone in Chronic Kidney and Cardiac Disease
J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2395 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
W. Qin, A. E. Rudolph, B. R. Bond, R. Rocha, E. A.G. Blomme, J. J. Goellner, J. W. Funder, and E. G. McMahon
Transgenic Model of Aldosterone-Driven Cardiac Hypertrophy and Heart Failure
Circ. Res., July 11, 2003; 93(1): 69 - 76.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. J. Young, L. Moussa, R. Dilley, and J. W. Funder
Early Inflammatory Responses in Experimental Cardiac Hypertrophy and Fibrosis: Effects of 11{beta}-Hydroxysteroid Dehydrogenase Inactivation
Endocrinology, March 1, 2003; 144(3): 1121 - 1125.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. I. McFarlane and J. R. Sowers
Aldosterone Function in Diabetes Mellitus: Effects on Cardiovascular and Renal Disease
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 516 - 523.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. D. Stockand and J. G. Meszaros
Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H176 - H184.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Sato, K. Hayashi, M. Naruse, and T. Saruta
Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy
Hypertension, January 1, 2003; 41(1): 64 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. J. Hausmann and N. Liel-Cohen
Aldactone therapy in a peritoneal dialysis patient with decreased left ventricular function
Nephrol. Dial. Transplant., November 1, 2002; 17(11): 2035 - 2036.
[Full Text] [PDF]

Home page
 HypertensionHome page
M. Naruse, A. Tanabe, A. Sato, S. Takagi, K. Tsuchiya, T. Imaki, and K. Takano
Aldosterone Breakthrough During Angiotensin II Receptor Antagonist Therapy in Stroke-Prone Spontaneously Hypertensive Rats
Hypertension, July 1, 2002; 40(1): 28 - 33.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Neumann, K. Huse, R. Semrau, A. Diegeler, R. Gebhardt, G. H. Buniatian, and G. H. Scholz
Aldosterone and D-Glucose Stimulate the Proliferation of Human Cardiac Myofibroblasts In Vitro
Hypertension, March 1, 2002; 39(3): 756 - 760.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. E. Sheppard and D. J. Autelitano
11{beta}-Hydroxysteroid Dehydrogenase 1 Transforms 11-Dehydrocorticosterone into Transcriptionally Active Glucocorticoid in Neonatal Rat Heart
Endocrinology, January 1, 2002; 143(1): 198 - 204.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Y. Takeda, T. Yoneda, M. Demura, I. Miyamori, and H. Mabuchi
Cardiac Aldosterone Production in Genetically Hypertensive Rats
Hypertension, October 1, 2000; 36(4): 495 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. C Wollert and H. Drexler
The renin-angiotensin system and experimental heart failure
Cardiovasc Res, September 1, 1999; 43(4): 838 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S.-Y. Chen, J. Wang, W. Liu, and D. Pearce
Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor
Am J Physiol Cell Physiol, January 1, 1998; 274(1): C39 - C46.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Sato, J.-P. Liu, and J. W. Funder
Aldosterone Rapidly Represses Protein Kinase C Activity in Neonatal Rat Cardiomyocytes in Vitro
Endocrinology, August 1, 1997; 138(8): 3410 - 3416.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society