| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Endocrinology, Vol 137, 4796-4805, Copyright © 1996 by Endocrine Society
ARTICLES |
EM Eddy, TF Washburn, DO Bunch, EH Goulding, BC Gladen, DB Lubahn and KS Korach
Gamete Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709-2233, USA. eddy@niehs.nih.gov
The reproductive system of male mice homozygous for a mutation in the estrogen receptor (ER) gene (ER knock-out; ERKO) appears normal at the anatomical level. However, these males are infertile, indicating an essential role for ER-mediated processes in the regulation of male reproduction. Adult ERKO male mice have significantly fewer epididymal sperm than heterozygous or wild-type males. Although spermatogenesis is occurring in some seminiferous tubules of 3- to 5-month-old ERKO males, other tubules either have a dilated lumen and a disorganized seminiferous epithelium with few spermatogenic cells or lack a lumen and contain mainly Sertoli cells. There are no obvious differences in seminiferous tubules at 10 days of age between wild-type and ERKO mice, but the lumen in ERKO males is dilated in all seminiferous tubules by 20 days. However, spermatogenesis progresses and similar numbers of sperm are present in the cauda epididymis of ERKO and wild-type males until 10 weeks of age. Disruption of spermatogenesis and degeneration of the seminiferous tubules become apparent after 10 weeks in the caudal pole of the testis and progresses in a wave to the cranial pole by 6 months. However, the seminal vesicles, coagulating glands, prostate, and epididymis do not appear to be altered morphologically in ERKO mice. Serum testosterone levels are somewhat elevated, but LH and FSH levels are not significantly different from those in wild-type males. Sperm from 8- to 16-week-old mice have reduced motility and are ineffective at fertilizing eggs in vitro. In addition, ERKO males housed overnight with hormone-primed wild-type females produce significantly fewer copulatory plugs than do heterozygous or wild-type males. These results suggest that estrogen action is required for fertility in male mice and that the mutation of the ER in ERKO males leads to reduced mating frequency, low sperm numbers, and defective sperm function.
This article has been cited by other articles:
![]() |
L. Strauss, J. Kallio, N. Desai, P. Pakarinen, T. Miettinen, H. Gylling, M. Albrecht, S. Makela, A. Mayerhofer, and M. Poutanen Increased Exposure to Estrogens Disturbs Maturation, Steroidogenesis, and Cholesterol Homeostasis via Estrogen Receptor {alpha} in Adult Mouse Leydig Cells Endocrinology, June 1, 2009; 150(6): 2865 - 2872. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. W. Sinkevicius, M. Laine, T. L. Lotan, K. Woloszyn, J. H. Richburg, and G. L. Greene Estrogen-Dependent and -Independent Estrogen Receptor-{alpha} Signaling Separately Regulate Male Fertility Endocrinology, June 1, 2009; 150(6): 2898 - 2905. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Chen, I. Hsu, A. Wolfe, S. Radovick, K. Huang, S. Yu, C. Chang, E. M. Messing, and S. Yeh Defects of Prostate Development and Reproductive System in the Estrogen Receptor-{alpha} Null Male Mice Endocrinology, January 1, 2009; 150(1): 251 - 259. [Abstract] [Full Text] [PDF] |
||||
![]() |
K L Hahn, B Beres, M. J Rowton, M K Skinner, Y Chang, A Rawls, and J Wilson-Rawls A deficiency of lunatic fringe is associated with cystic dilation of the rete testis Reproduction, January 1, 2009; 137(1): 79 - 93. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Otto, I. Fuchs, G. Kauselmann, H. Kern, B. Zevnik, P. Andreasen, G. Schwarz, H. Altmann, M. Klewer, M. Schoor, et al. GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice Biol Reprod, January 1, 2009; 80(1): 34 - 41. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Weiss, M. L. Bernhardt, M. M. Laronda, L. A. Hurley, C. Glidewell-Kenney, S. Pillai, M. Tong, K. S. Korach, and J. L. Jameson Estrogen Actions in the Male Reproductive System Involve Estrogen Response Element-Independent Pathways Endocrinology, December 1, 2008; 149(12): 6198 - 6206. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Mennigen, C. J. Martyniuk, K. Crump, H. Xiong, E. Zhao, J. Popesku, H. Anisman, A. R. Cossins, X. Xia, and V. L. Trudeau Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus) Physiol Genomics, November 12, 2008; 35(3): 273 - 282. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Lange, Y. Katsu, R. Ichikawa, G. C. Paull, L. L. Chidgey, T. S. Coe, T. Iguchi, and C. R. Tyler Altered Sexual Development in Roach (Rutilus rutilus) Exposed to Environmental Concentrations of the Pharmaceutical 17{alpha}-Ethinylestradiol and Associated Expression Dynamics of Aromatases and Estrogen Receptors Toxicol. Sci., November 1, 2008; 106(1): 113 - 123. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Toda, T. Okada, Y. Hayashi, and T. Saibara Preserved tissue structure of efferent ductules in aromatase-deficient mice J. Endocrinol., October 1, 2008; 199(1): 137 - 146. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Yasuhara, G. R. O. Gomes, E. R. Siu, C. I. Suenaga, E. Marostica, C. S. Porto, and M. F. M. Lazari Effects of the Antiestrogen Fulvestrant (ICI 182,780) on Gene Expression of the Rat Efferent Ductules Biol Reprod, September 1, 2008; 79(3): 432 - 441. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Ye, M. K. Skinner, G. Kennedy, and J. Chun Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling Biol Reprod, August 1, 2008; 79(2): 328 - 336. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Meeker, N. P. Singh, and R. Hauser Serum Concentrations of Estradiol and Free T4 Are Inversely Correlated With Sperm DNA Damage in Men From an Infertility Clinic J Androl, July 1, 2008; 29(4): 379 - 388. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wahlgren, K. Svechnikov, M.-L. Strand, K. Jahnukainen, M. Parvinen, J.-A. Gustafsson, and O. Soder Estrogen Receptor {beta} Selective Ligand 5{alpha}-Androstane-3{beta}, 17{beta}-Diol Stimulates Spermatogonial Deoxyribonucleic Acid Synthesis in Rat Seminiferous Epithelium in Vitro Endocrinology, June 1, 2008; 149(6): 2917 - 2922. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Akimoto, H. Kitagawa, T. Matsumoto, and S. Kato Spermatogenesis-specific association of SMCY and MSH5. Genes Cells, June 1, 2008; 13(6): 623 - 633. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wellejus, H. E. Jensen, S. Loft, and T. E. Jonassen Expression of Aquaporin 9 in Rat Liver and Efferent Ducts of the Male Reproductive System After Neonatal Diethylstilbestrol Exposure J. Histochem. Cytochem., May 1, 2008; 56(5): 425 - 432. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Montani, M. Penza, M. Jeremic, G. Biasiotto, G. La Sala, M. De Felici, P. Ciana, A. Maggi, and D. Di Lorenzo Genistein is an Efficient Estrogen in the Whole-Body throughout Mouse Development Toxicol. Sci., May 1, 2008; 103(1): 57 - 67. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. F.G Lucas, E. R Siu, C. A Esteves, H. P Monteiro, C. A Oliveira, C. S Porto, and M. F. M Lazari 17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells Biol Reprod, January 1, 2008; 78(1): 101 - 114. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Mhaouty-Kodja, A. Lozach, R. Habert, M. Tanneux, C. Guigon, S. Brailly-Tabard, J.-P. Maltier, and C. Legrand-Maltier Fertility and spermatogenesis are altered in {alpha}1b-adrenergic receptor knockout male mice J. Endocrinol., November 1, 2007; 195(2): 281 - 292. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A. McDevitt, C. Glidewell-Kenney, J. Weiss, P. Chambon, J. L. Jameson, and J. E. Levine Estrogen Response Element-Independent Estrogen Receptor (ER)-{alpha} Signaling Does Not Rescue Sexual Behavior but Restores Normal Testosterone Secretion in Male ER{alpha} Knockout Mice Endocrinology, November 1, 2007; 148(11): 5288 - 5294. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Zhongyi, P. Rantakari, T. Lamminen, J. Toppari, and M. Poutanen Transgenic Male Mice Expressing Human Hydroxysteroid Dehydrogenase 2 Indicate a Role for the Enzyme Independent of Its Action on Sex Steroids Endocrinology, August 1, 2007; 148(8): 3827 - 3836. [Abstract] [Full Text] [PDF] |
||||
![]() |
G.-R. Chen, R.-S. Ge, H. Lin, L. Dong, C. M. Sottas, and M. P. Hardy Development of a cryopreservation protocol for Leydig cells Hum. Reprod., August 1, 2007; 22(8): 2160 - 2168. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Yu, X. Wang, C.-F. Ng, S. Chen, and F. L. Chan ERR{gamma} Suppresses Cell Proliferation and Tumor Growth of Androgen-Sensitive and Androgen-Insensitive Prostate Cancer Cells and Its Implication as a Therapeutic Target for Prostate Cancer Cancer Res., May 15, 2007; 67(10): 4904 - 4914. [Abstract] [Full Text] [PDF] |
||||
![]() |
H O Goyal, T D Braden, P S Cooke, M A Szewczykowski, C S Williams, P Dalvi, and J W Williams Estrogen receptor-{alpha} mediates estrogen-inducible abnormalities in the developing penis Reproduction, May 1, 2007; 133(5): 1057 - 1067. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Chen, M. L Nagpal, D. M Stocco, and T. Lin Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells J. Endocrinol., March 1, 2007; 192(3): 527 - 537. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Wierman Sex steroid effects at target tissues: mechanisms of action Advan Physiol Educ, March 1, 2007; 31(1): 26 - 33. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Assinder, R. Davis, M. Fenwick, and A. Glover Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells Reproduction, January 1, 2007; 133(1): 11 - 19. [Abstract] [Full Text] [PDF] |
||||
![]() |
A Glover and S J Assinder Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression. J. Endocrinol., June 1, 2006; 189(3): 565 - 573. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. D. Anway and M. K. Skinner Epigenetic Transgenerational Actions of Endocrine Disruptors Endocrinology, June 1, 2006; 147(6): s43 - s49. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Handelsman The Rationale for Banning Human Chorionic Gonadotropin and Estrogen Blockers in Sport J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1646 - 1653. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Guarducci, F. Nuti, L. Becherini, M. Rotondi, G. Balercia, G. Forti, and C. Krausz Estrogen receptor {alpha} promoter polymorphism: stronger estrogen action is coupled with lower sperm count Hum. Reprod., April 1, 2006; 21(4): 994 - 1001. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. S. Devi, K. Sarda, B. Stephen, P. Nagarajan, and S. S. Majumdar Follicle-Stimulating Hormone-Independent Functions of Primate Sertoli Cells: Potential Implications in the Diagnosis and Management of Male Infertility J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1062 - 1068. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Roy and M. M Matzuk Deconstructing mammalian reproduction: using knockouts to define fertility pathways Reproduction, February 1, 2006; 131(2): 207 - 219. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Vernet, C. Dennefeld, C. Rochette-Egly, M. Oulad-Abdelghani, P. Chambon, N. B. Ghyselinck, and M. Mark Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis Endocrinology, January 1, 2006; 147(1): 96 - 110. [Abstract] [Full Text] [PDF] |
||||
![]() |
E.E. At-Taras, A.J. Conley, T. Berger, and J.F. Roser Reducing Estrogen Synthesis Does Not Affect Gonadotropin Secretion in the Developing Boar Biol Reprod, January 1, 2006; 74(1): 58 - 66. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Baines, M. O Nwagwu, E. C Furneaux, J. Stewart, J. B Kerr, T. M Mayhew, and F. J P Ebling Estrogenic induction of spermatogenesis in the hypogonadal (hpg) mouse: role of androgens Reproduction, November 1, 2005; 130(5): 643 - 654. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Li, C. A. Putnam-Lawson, H. Knapp-Hoch, P. J. Friel, D. Mitchell, R. Hively, and M. D. Griswold Immunolocalization and Regulation of Cystatin 12 in Mouse Testis and Epididymis Biol Reprod, November 1, 2005; 73(5): 872 - 880. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. L. Matthiesson, P. G. Stanton, L. O'Donnell, S. J. Meachem, J. K. Amory, R. Berger, W. J. Bremner, and R. I. McLachlan Effects of Testosterone and Levonorgestrel Combined with a 5{alpha}-Reductase Inhibitor or Gonadotropin-Releasing Hormone Antagonist on Spermatogenesis and Intratesticular Steroid Levels in Normal Men J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5647 - 5655. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. B Rulli and I. Huhtaniemi What have gonadotrophin overexpressing transgenic mice taught us about gonadal function? Reproduction, September 1, 2005; 130(3): 283 - 291. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Naciff, K. A. Hess, G. J. Overmann, S. M. Torontali, G. J. Carr, J. P. Tiesman, L. M. Foertsch, B. D. Richardson, J. E. Martinez, and G. P. Daston Gene Expression Changes Induced in the Testis by Transplacental Exposure to High and Low Doses of 17{alpha}-Ethynyl Estradiol, Genistein, or Bisphenol A Toxicol. Sci., August 1, 2005; 86(2): 396 - 416. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Khaira, D. McLean, D. A. Ohl, and G. D. Smith Spermatogonial Stem Cell Isolation, Storage, and Transplantation J Androl, July 1, 2005; 26(4): 442 - 450. [Full Text] [PDF] |
||||
![]() |
W. Jin, K. Y. Arai, G. Watanabe, A. K. Suzuki, S. Takahashi, and K. Taya The Stimulatory Role of Estrogen on Sperm Motility in the Male Golden Hamster (Mesocricetus auratus) J Androl, July 1, 2005; 26(4): 478 - 484. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J Meachem, D. M Robertson, N. G Wreford, R. I McLachlan, and P. G Stanton Oestrogen does not affect the restoration of spermatogenesis in the gonadotrophin-releasing hormone-immunised adult rat J. Endocrinol., June 1, 2005; 185(3): 529 - 538. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Delbes, C. Levacher, C. Duquenne, C. Racine, P. Pakarinen, and R. Habert Endogenous Estrogens Inhibit Mouse Fetal Leydig Cell Development via Estrogen Receptor {alpha} Endocrinology, May 1, 2005; 146(5): 2454 - 2461. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. P. Mishra and C. Shaha Estrogen-induced Spermatogenic Cell Apoptosis Occurs via the Mitochondrial Pathway: ROLE OF SUPEROXIDE AND NITRIC OXIDE J. Biol. Chem., February 18, 2005; 280(7): 6181 - 6196. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. R. Chakraborty, G. Rajendren, and A. C. Gore Expression of Estrogen Receptor {alpha} in the Anteroventral Periventricular Nucleus of Hypogonadal Mice Experimental Biology and Medicine, January 1, 2005; 230(1): 49 - 56. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. O. Goyal, T. D. Braden, C. S. Williams, P. Dalvi, M. M. Mansour, and J. W. Williams Permanent Induction of Morphological Abnormalities in the Penis and Penile Skeletal Muscles in Adult Rats Treated Neonatally With Diethylstilbestrol or Estradiol Valerate: A Dose-Response Study J Androl, January 1, 2005; 26(1): 32 - 43. [Abstract] [Full Text] [PDF] |
||||
![]() |
L Hilakivi-Clarke, C Wang, M Kalil, R Riggins, and R G Pestell Nutritional modulation of the cell cycle and breast cancer Endocr. Relat. Cancer, December 1, 2004; 11(4): 603 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H. Herynk and S. A. W. Fuqua Estrogen Receptor Mutations in Human Disease Endocr. Rev., December 1, 2004; 25(6): 869 - 898. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Wang, R. Thuillier, and M. Culty Prenatal Estrogen Exposure Differentially Affects Estrogen Receptor-Associated Proteins in Rat Testis Gonocytes Biol Reprod, November 1, 2004; 71(5): 1652 - 1664. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A Oliveira, G. A B Mahecha, K. Carnes, G. S Prins, P. T K Saunders, L. R Franca, and R. A Hess Differential hormonal regulation of estrogen receptors ER{alpha} and ER{beta} and androgen receptor expression in rat efferent ductules Reproduction, July 1, 2004; 128(1): 73 - 86. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Hermo, D. Krzeczunowicz, and R. Ruz Cell Specificity of Aquaporins 0, 3, and 10 Expressed in the Testis, Efferent Ducts, and Epididymis of Adult Rats J Androl, July 1, 2004; 25(4): 494 - 505. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Delbes, C. Levacher, C. Pairault, C. Racine, C. Duquenne, A. Krust, and R. Habert Estrogen Receptor {beta}-Mediated Inhibition of Male Germ Cell Line Development in Mice by Endogenous Estrogens during Perinatal Life Endocrinology, July 1, 2004; 145(7): 3395 - 3403. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H. Tong, L. K. Christenson, and W.-C. Song Aberrant Cholesterol Transport and Impaired Steroidogenesis in Leydig Cells Lacking Estrogen Sulfotransferase Endocrinology, May 1, 2004; 145(5): 2487 - 2497. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.O. Goyal, T.D. Braden, C.S. Williams, P. Dalvi, M.M. Mansour, M. Mansour, J.W. Williams, F.F. Bartol, A.A. Wiley, L. Birch, et al. Abnormal Morphology of the Penis in Male Rats Exposed Neonatally to Diethylstilbestrol Is Associated with Altered Profile of Estrogen Receptor-{alpha} Protein, but Not of Androgen Receptor Protein: A Developmental and Immunocytochemical Study Biol Reprod, May 1, 2004; 70(5): 1504 - 1517. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Srinivasan, D. O. Bunch, Y. Feng, R. M. Rodriguiz, M. Li, R. L. Ravenell, G. X. Luo, A. Arimura, L. D. Fricker, E. M. Eddy, et al. Deficits in Reproduction and Pro-Gonadotropin-Releasing Hormone Processing in Male Cpefat Mice Endocrinology, April 1, 2004; 145(4): 2023 - 2034. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. D. Albrecht, R. B. Billiar, G. W. Aberdeen, J. S. Babischkin, and G. J. Pepe Expression of Estrogen Receptors {alpha} and {beta} in the Fetal Baboon Testisand Epididymis Biol Reprod, April 1, 2004; 70(4): 1106 - 1113. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Aquila, D. Sisci, M. Gentile, E. Middea, S. Catalano, A. Carpino, V. Rago, and S. Ando Estrogen Receptor (ER){alpha} and ER{beta} Are Both Expressed in Human Ejaculated Spermatozoa: Evidence of Their Direct Interaction with Phosphatidylinositol-3-OH Kinase/Akt Pathway J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1443 - 1451. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Ma, J. Graves, J. A. Bradbury, Y. Zhao, D. L. Swope, L. King, W. Qu, J. Clark, P. Myers, V. Walker, et al. Regulation of Mouse Renal CYP2J5 Expression by Sex Hormones Mol. Pharmacol., March 1, 2004; 65(3): 730 - 743. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Li, L. Strauss, S. Makela, T. Streng, I. Huhtaniemi, R. Santti, and M. Poutanen Multiple Structural and Functional Abnormalities in the P450 Aromatase Expressing Transgenic Male Mice Are Ameliorated by a P450 Aromatase Inhibitor Am. J. Pathol., March 1, 2004; 164(3): 1039 - 1048. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-H. Qiu, M. Ohe, N. Koibuchi, and S. Matsuzaki Apoptosis in the Epididymal Epithelium of Adult Male Golden Hamster Exposed to Diethylstilbestrol J. Histochem. Cytochem., February 1, 2004; 52(2): 187 - 192. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Ochiai, K.-i. Matsuda, M. Nishi, H. Ozawa, and M. Kawata Imaging Analysis of Subcellular Correlation of Androgen Receptor and Estrogen Receptor {alpha} in Single Living Cells Using Green Fluorescent Protein Color Variants Mol. Endocrinol., January 1, 2004; 18(1): 26 - 42. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Sipila, R. Shariatmadari, I. T. Huhtaniemi, and M. Poutanen Immortalization of Epididymal Epithelium in Transgenic Mice Expressing Simian Virus 40 T Antigen: Characterization of Cell Lines and Regulation of the Polyoma Enhancer Activator 3 Endocrinology, January 1, 2004; 145(1): 437 - 446. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Miura, T. Ohta, C. I. Miura, and K. Yamauchi Complementary Deoxyribonucleic Acid Cloning of Spermatogonial Stem Cell Renewal Factor Endocrinology, December 1, 2003; 144(12): 5504 - 5510. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. B. Rulli, P. Ahtiainen, S. Makela, J. Toppari, M. Poutanen, and I. Huhtaniemi Elevated Steroidogenesis, Defective Reproductive Organs, and Infertility in Transgenic Male Mice Overexpressing Human Chorionic Gonadotropin Endocrinology, November 1, 2003; 144(11): 4980 - 4990. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.Y. Man, J. Clulow, and R.C. Jones Signal Transduction in the Ductuli Efferentes Testis of the Rat: Inhibition of Fluid Reabsorption by Cyclic Adenosine 3', 5'-Monophosphate Biol Reprod, November 1, 2003; 69(5): 1714 - 1718. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Aquila, D. Sisci, M. Gentile, A. Carpino, E. Middea, S. Catalano, V. Rago, and S. Ando Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm Hum. Reprod., August 1, 2003; 18(8): 1650 - 1659. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. R. Maduro, K. C. Lo, W. W. Chuang, and D. J. Lamb Genes and Male Infertility: What Can Go Wrong? J Androl, July 1, 2003; 24(4): 485 - 493. [Full Text] [PDF] |
||||
![]() |
H.O. Goyal, A. Robateau, T.D. Braden, C.S. Williams, K.K. Srivastava, and K. Ali Neonatal Estrogen Exposure of Male Rats Alters Reproductive Functions at Adulthood Biol Reprod, June 1, 2003; 68(6): 2081 - 2091. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Catalano, V. Pezzi, A. Chimento, C. Giordano, A. Carpino, M. Young, M. J. McPhaul, and S. Ando Triiodothyronine Decreases the Activity of the Proximal Promoter (PII) of the Aromatase Gene in the Mouse Sertoli Cell Line, TM4 Mol. Endocrinol., May 1, 2003; 17(5): 923 - 934. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Dufour, M.-N. Vo, N. Bhattacharya, J. Okita, R. Okita, and K. H. Kim Peroxisome Proliferators Disrupt Retinoic Acid Receptor Alpha Signaling in the Testis Biol Reprod, April 1, 2003; 68(4): 1215 - 1224. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Thuillier, Y. Wang, and M. Culty Prenatal Exposure to Estrogenic Compounds Alters the Expression Pattern of Platelet-Derived Growth Factor Receptors {alpha} and {beta} in Neonatal Rat Testis: Identification of Gonocytes as Targets of Estrogen Exposure Biol Reprod, March 1, 2003; 68(3): 867 - 880. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. H. Thin, L. Wang, E. Kim, L. L. Collins, R. Basavappa, and C. Chang Isolation and Characterization of Androgen Receptor Mutant, AR(M749L), with Hypersensitivity to 17-beta Estradiol Treatment J. Biol. Chem., February 21, 2003; 278(9): 7699 - 7708. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. T. Akingbemi, R. Ge, C. S. Rosenfeld, L. G. Newton, D. O. Hardy, J. F. Catterall, D. B. Lubahn, K. S. Korach, and M. P. Hardy Estrogen Receptor-{alpha} Gene Deficiency Enhances Androgen Biosynthesis in the Mouse Leydig Cell Endocrinology, January 1, 2003; 144(1): 84 - 93. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Rivas, J. S. Fisher, C. McKinnell, N. Atanassova, and R. M. Sharpe Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrogen Balance Endocrinology, December 1, 2002; 143(12): 4797 - 4808. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Zhou, R. Nie, G. S. Prins, P. T. K. Saunders, B. S. Katzenellenbogen, and R. A. Hess Localization of Androgen and Estrogen Receptors in Adult Male Mouse Reproductive Tract J Androl, November 1, 2002; 23(6): 870 - 881. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. R. Pak, G. R. Lynch, and P.-S. Tsai Differential Alteration of the Reproductive Axis by Testosterone and Estrogen in Peripubertal and Adult Male Siberian Hamsters (Phodopus sungorus) Biol Reprod, September 1, 2002; 67(3): 706 - 711. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. R. Fielden, R. G. Halgren, C. J. Fong, C. Staub, L. Johnson, K. Chou, and T. R. Zacharewski Gestational and Lactational Exposure of Male Mice to Diethylstilbestrol Causes Long-Term Effects on the Testis, Sperm Fertilizing Ability in Vitro, and Testicular Gene Expression Endocrinology, August 1, 2002; 143(8): 3044 - 3059. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H. Tong and W.-C. Song Estrogen Sulfotransferase: Discrete and Androgen-Dependent Expression in the Male Reproductive Tract and Demonstration of an in Vivo Function in the Mouse Epididymis Endocrinology, August 1, 2002; 143(8): 3144 - 3151. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Aquila, D. Sisci, M. Gentile, E. Middea, L. Siciliano, and S. Ando Human Ejaculated Spermatozoa Contain Active P450 Aromatase J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3385 - 3390. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. Oliveira, Q. Zhou, K. Carnes, R. Nie, D. E. Kuehl, G. L. Jackson, L. R. Franca, M. Nakai, and R. A. Hess ER Function in the Adult Male Rat: Short- and Long-Term Effects of the Antiestrogen ICI 182,780 on the Testis and Efferent Ductules, without Changes in Testosterone Endocrinology, June 1, 2002; 143(6): 2399 - 2409. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Pare, A. Krust, R. H. Karas, S. Dupont, M. Aronovitz, P. Chambon, and M. E. Mendelsohn Estrogen Receptor-{alpha} Mediates the Protective Effects of Estrogen Against Vascular Injury Circ. Res., May 31, 2002; 90(10): 1087 - 1092. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. H. Badran and L. S. Hermo Expression and Regulation of Aquaporins 1, 8, and 9 in the Testis, Efferent Ducts, and Epididymis of Adult Rats and During Postnatal Development J Androl, May 1, 2002; 23(3): 358 - 373. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-R. Shyr, Y.-C. Hu, E. Kim, and C. Chang Modulation of Estrogen Receptor-mediated Transactivation by Orphan Receptor TR4 in MCF-7 Cells J. Biol. Chem., April 19, 2002; 277(17): 14622 - 14628. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Nie, Q. Zhou, E. Jassim, P. T.K. Saunders, and R. A. Hess Differential Expression of Estrogen Receptors {alpha} and {beta} in the Reproductive Tractsof Adult Male Dogs and Cats Biol Reprod, April 1, 2002; 66(4): 1161 - 1168. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Meng, H. Akutsu, K. Schoene, C. Reifsteck, E. P. Fox, S. Olson, H. Sariola, R. Yanagimachi, and M. Baetscher Transgene Insertion Induced Dominant Male Sterility and Rescue of Male Fertility Using Round Spermatid Injection Biol Reprod, March 1, 2002; 66(3): 726 - 734. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. G. de Rooij, H. J.G. van de Kant, R. Dol, G. Wagemaker, P. P.W. van Buul, A. van Duijn-Goedhart, F. H. de Jong, and J. J. Broerse Long-Term Effects of Irradiation Before Adulthood on Reproductive Function in the Male Rhesus Monkey Biol Reprod, February 1, 2002; 66(2): 486 - 494. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. L. Smith, D. G. DeVera, D. J. Lamb, Z. Nawaz, Y.-H. Jiang, A. L. Beaudet, and B. W. O'Malley Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction Mol. Cell. Biol., January 15, 2002; 22(2): 525 - 535. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Cobellis, R. Meccariello, G. Fienga, R. Pierantoni, and S. Fasano Cytoplasmic and Nuclear Fos Protein Forms Regulate Resumption of Spermatogenesis in the Frog, Rana esculenta Endocrinology, January 1, 2002; 143(1): 163 - 170. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tsukahara and K. Yamanouchi Sex Difference in Septal Neurons Projecting Axons to Midbrain Central Gray in Rats: A Combined Double Retrograde Tracing and ER-Immunohistochemical Study Endocrinology, January 1, 2002; 143(1): 285 - 294. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. M. Qian, X. J. Sun, M. H. Tong, X. P. Li, J. Richa, and W.-C. Song Targeted Disruption of the Mouse Estrogen Sulfotransferase Gene Reveals a Role of Estrogen Metabolism in Intracrine and Paracrine Estrogen Regulation Endocrinology, December 1, 2001; 142(12): 5342 - 5350. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. R. Simpson and S. R. Davis Minireview: Aromatase and the Regulation of Estrogen Biosynthesis--Some New Perspectives Endocrinology, November 1, 2001; 142(11): 4589 - 4594. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-H. Lee, C. Finnigan-Bunick, J. Bahr, and D. Bunick Estrogen Regulation of Ion Transporter Messenger RNA Levels in Mouse Efferent Ductules Are Mediated Differentially Through Estrogen Receptor (ER) {alpha} and ER{beta} Biol Reprod, November 1, 2001; 65(5): 1534 - 1541. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Zhou, L. Clarke, R. Nie, K. Carnes, L.-W. Lai, Y.-H. H. Lien, A. Verkman, D. Lubahn, J. S. Fisher, B. S. Katzenellenbogen, et al. Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function PNAS, October 31, 2001; (2001) 241245898. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. R. Levin Genome and Hormones: Gender Differences in Physiology: Invited Review: Cell localization, physiology, and nongenomic actions of estrogen receptors J Appl Physiol, October 1, 2001; 91(4): 1860 - 1867. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Jeffs, J. J. Meeks, M. Ito, F. A. Martinson, M. M. Matzuk, J. L. Jameson, and L. D. Russell Blockage of the Rete Testis and Efferent Ductules by Ectopic Sertoli and Leydig Cells Causes Infertility in Dax1-Deficient Male Mice Endocrinology, October 1, 2001; 142(10): 4486 - 4495. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-A. Gustafsson Mechanisms of Estrogen Action Physiol Rev, October 1, 2001; 81(4): 1535 - 1565. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Larrea, R. Garcia-Becerra, A. E. Lemus, G. A. Garcia, G. Perez-Palacios, K. J. Jackson, K. M. Coleman, R. Dace, C. L. Smith, and A. J. Cooney A-Ring Reduced Metabolites of 19-nor Synthetic Progestins as Subtype Selective Agonists for ER{alpha} Endocrinology, September 1, 2001; 142(9): 3791 - 3799. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. Oliveira, K. Carnes, L. R. Franca, and R. A. Hess Infertility and Testicular Atrophy in the Antiestrogen-Treated Adult Male Rat Biol Reprod, September 1, 2001; 65(3): 913 - 920. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |