Endocrinology, Vol 137, 504-507, Copyright © 1996 by Endocrine Society

ARTICLES

Roles of the suprachiasmatic nucleus and vasoactive intestinal peptide in the response of plasma arginine vasopressin to osmotic challenge

N Nagai, K Nagai, SJ Chun, K Shimizu, K Takezawa, M Tsuji, K Sugahara and H Nakagawa
Division of Protein Metabolism, Osaka University, Japan.

To clarify the role of neurons containing a vasoactive intestinal peptide (VIP)-like substance (VIP neurons) in the hypothalamic suprachiasmatic nucleus (SCN) in regulation of the plasma arginine vasopressin (AVP) concentration, we examined the effects of bilateral lesions of the SCN and intracranial injection of VIP on the increase in the plasma AVP concentration caused by ip injection of hypertonic (3.6%) saline in rats. The increase in the plasma AVP concentration after ip injection of hypertonic saline was significantly suppressed in rats with bilateral lesions of the SCN. Furthermore, the increase in the plasma AVP concentration elicited by ip injection of hypertonic saline was enhanced by intracerebro-ventricular injection of VIP and suppressed by a VIP antagonist, [Lys1,Pro2,5,Arg3.4,Tyr6]VIP. However, the same dose of VIP injected into the heart had no effect on the increase in the plasma AVP concentration caused by ip injection of hypertonic saline. These results suggest that the SCN and intracranial VIP play important roles in the regulation of the plasma AVP concentration and support the possibility that VIP neurons in the SCN enhance the response of plasma AVP to osmotic challenge.

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