help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iglesias-Barreira, V.
Right arrow Articles by Remacle, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iglesias-Barreira, V.
Right arrow Articles by Remacle, C.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Dietary Proteins
*Seniors' Health
Hazardous Substances DB
*GLUCOSE

Endocrinology, Vol 137, 3797-3801, Copyright © 1996 by Endocrine Society

ARTICLES

Pre- and postnatal low protein diet affect pancreatic islet blood flow and insulin release in adult rats

V Iglesias-Barreira, MT Ahn, B Reusens, S Dahri, JJ Hoet and C Remacle
Laboratoire de Biologie Cellulaire, Universite Catholique de Louvain, Louvain-La Neuve, Belgium.

The pancreatic islet blood flow and insulin secretion of adult rats submitted to an isocaloric low protein diet (8% vs. 20%) during pre- and postnatal life were investigated by the nonradioactive microsphere technique. In the basal state, female rats chronically exposed to a low protein diet (LP) displayed a specific marked decrease in islet blood flow (10 +/- 2 vs. 29 +/- 5 microliters/min.g pancreas; P < 0.01) and overall pancreatic blood flow (P < 0.01). The plasma insulin level, however, was not affected. During a glucose challenge, the control animals enhanced their islet blood flow 2.3-fold, whereas the LP group reached control values with a 6-fold increase. Plasma insulin levels rose similarly in the control and LP animals. A third group of animals designated the recuperation group, exposed to a low protein diet only in utero, displayed islet blood flow comparable to control values, but increased basal plasma insulin (2.0 +/- 0.3 vs. 1.2 +/- 0.1 ng/ml; P < 0.05). These data are consistent with the possibility of dissociation of islet blood flow and insulin release under basal conditions, which may not be the case after a glucose challenge. Furthermore, the low blood flow values in the LP group may reflect an adaptive physiological response, an impaired pancreatic vasculogenesis, or a dysfunction of endothelial cells.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
I. C. Mcmillen and J. S. Robinson
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Physiol Rev, April 1, 2005; 85(2): 571 - 633.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
A. L Fowden and D. J Hill
Intra-uterine programming of the endocrine pancreas
Br. Med. Bull., November 1, 2001; 60(1): 123 - 142.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
N. Bennis-Taleb, C. Remacle, J. J. Hoet, and B. Reusens
A Low-Protein Isocaloric Diet During Gestation Affects Brain Development and Alters Permanently Cerebral Cortex Blood Vessels in Rat Offspring
J. Nutr., August 1, 1999; 129(8): 1613 - 1619.
[Abstract] [Full Text]

Home page
 BMJHome page
P. Poulsen, A. Vaag, and H. Beck-Nielsen
Does zygosity influence the metabolic profile of twins? A population based cross sectional study
BMJ, July 17, 1999; 319(7203): 151 - 154.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society