help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O’Shea, D.
Right arrow Articles by Bloom, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O’Shea, D.
Right arrow Articles by Bloom, S. R.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Endocrinology Vol. 138, No. 1 196-202
Copyright © 1997 by The Endocrine Society

ARTICLES

Neuropeptide Y Induced Feeding in the Rat Is Mediated by a Novel Receptor1

D. O’Shea2, D. G. A. Morgan3, K. Meeran4, C. M. B. Edwards, M. D. Turton, S. J. Choi, M. M. Heath3, I. Gunn, G. M. Taylor3, J. K. Howard4, C. I. Bloom, C. J. Small5, O. Haddo, J. J. Ma, W. Callinan, D. M. Smith, M. A. Ghatei and S. R. Bloom

Division of Endocrinology and Metabolic Medicine, Department of Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, United Kingdom

Address all correspondence and requests for reprints to: Professor S. R. Bloom, Division of Endocrinology and Metabolic Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom. E-mail: sbloom{at}rpms.ac.uk

There are now six recognized neuropeptide Y (NPY) receptor subtypes (Y1–Y4 and two recently cloned distinct receptors labeled Y5), of which Y1 and one of the Y5’s have been suggested could mediate the effect of NPY on feeding. The fragments NPY(2–36) and NPY(3–36), which bind Y1 only poorly, were injected intracerebroventricularly (icv) and found to have similar dose-response relationships to NPY in the stimulation of feeding. However NPY(13–36), which stimulates both Y2 and Y5, caused no increase in food intake, even at high doses. Maximal stimulation with the classical Y1 agonist [Pro34]-NPY produced only 50% of the maximum effect of NPY itself despite fully inhibiting adenylyl cyclase activity in vitro in a Y1 system. The novel fragment [Pro34]-NPY(3–36) is as effective at stimulating food intake as the classical Y1 analogue [Pro34]-NPY but bound to the Y1 receptor with only 1/20th of the affinity of NPY and failed to inhibit adenylyl cyclase through this receptor. [Pro34]-NPY(3–36) is therefore a relatively appetite-selective ligand. Coadministration of high dose NPY(13–36) and [Pro34]NPY did not enhance feeding compared with [Pro34]-NPY alone. In addition, the NPY Y1 receptor antagonist BIBP-3226, which does not bind Y2, Y4, or Y5 receptors, significantly reduced NPY induced feeding. These results indicate that the feeding effect of icv NPY involves a novel receptor and that it is functionally distinct from the recognized receptor subtypes.




This article has been cited by other articles:


Home page
 DiabetesHome page
P. Pissios, U. Ozcan, E. Kokkotou, T. Okada, C. W. Liew, S. Liu, J. N. Peters, G. Dahlgren, J. Karamchandani, Y. C. Kudva, et al.
Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth
Diabetes, February 1, 2007; 56(2): 311 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
B Beck
Neuropeptide Y in normal eating and in genetic and dietary-induced obesity
Phil Trans R Soc B, July 29, 2006; 361(1471): 1159 - 1185.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Kuramochi, T. Onaka, D. Kohno, S. Kato, and T. Yada
Galanin-Like Peptide Stimulates Food Intake via Activation of Neuropeptide Y Neurons in the Hypothalamic Dorsomedial Nucleus of the Rat
Endocrinology, April 1, 2006; 147(4): 1744 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. Wynne, S. Stanley, B. McGowan, and S. Bloom
Appetite control
J. Endocrinol., February 1, 2005; 184(2): 291 - 318.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. M. Kong, N. M. Martin, K. L. Smith, J. V. Gardiner, I. P. Connoley, D. A. Stephens, W. S. Dhillo, M. A. Ghatei, C. J. Small, and S. R. Bloom
Triiodothyronine Stimulates Food Intake via the Hypothalamic Ventromedial Nucleus Independent of Changes in Energy Expenditure
Endocrinology, November 1, 2004; 145(11): 5252 - 5258.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Andersson, K. Filipsson, C. R. Abbott, A. Woods, K. Smith, S. R. Bloom, D. Carling, and C. J. Small
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
J. Biol. Chem., March 26, 2004; 279(13): 12005 - 12008.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. M. Berglund, P. A. Hipskind, and D. R. Gehlert
Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes
Experimental Biology and Medicine, March 1, 2003; 228(3): 217 - 244.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. V. Turnbull, L. Ellershaw, D. J. Masters, S. Birtles, S. Boyer, D. Carroll, P. Clarkson, S. J.G. Loxham, P. McAulay, J. L. Teague, et al.
Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats
Diabetes, August 1, 2002; 51(8): 2441 - 2449.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Pronchuk, A. G. Beck-Sickinger, and W. F. Colmers
Multiple NPY Receptors Inhibit GABAA Synaptic Responses of Rat Medial Parvocellular Effector Neurons in the Hypothalamic Paraventricular Nucleus
Endocrinology, February 1, 2002; 143(2): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. L. Chaffer and M. J. Morris
The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat
Endocrinology, January 1, 2002; 143(1): 191 - 197.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. H. Russell, C. J. Small, A. R. Kennedy, S. A. Stanley, A. Seth, K. G. Murphy, S. Taheri, M. A. Ghatei, and S. R. Bloom
Orexin A Interactions in the Hypothalamo-Pituitary Gonadal Axis
Endocrinology, December 1, 2001; 142(12): 5294 - 5302.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Zammaretti, G. Panzica, and C. Eva
Fasting, Leptin Treatment, and Glucose Administration Differentially Regulate Y1 Receptor Gene Expression in the Hypothalamus of Transgenic Mice
Endocrinology, September 1, 2001; 142(9): 3774 - 3782.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Kanatani, M. Hata, S. Mashiko, A. Ishihara, O. Okamoto, Y. Haga, T. Ohe, T. Kanno, N. Murai, Y. Ishii, et al.
A Typical Y1 Receptor Regulates Feeding Behaviors: Effects of a Potent and Selective Y1 Antagonist, J-115814
Mol. Pharmacol., March 1, 2001; 59(3): 501 - 505.
[Abstract] [Full Text]

Home page
 DiabetesHome page
C. J. Small, M. S. Kim, S. A. Stanley, J. R.D. Mitchell, K. Murphy, D. G.A. Morgan, M. A. Ghatei, and S. R. Bloom
Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals
Diabetes, February 1, 2001; 50(2): 248 - 254.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
A. Kanatani, S. Mashiko, N. Murai, N. Sugimoto, J. Ito, T. Fukuroda, T. Fukami, N. Morin, D. J. MacNeil, L. H. T. Van der Ploeg, et al.
Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice
Endocrinology, March 1, 2000; 141(3): 1011 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. Wraith, A. Törnsten, P. Chardon, I. Harbitz, B. P. Chowdhary, L. Andersson, L.-G. Lundin, and D. Larhammar
Evolution of the Neuropeptide Y Receptor Family: Gene and Chromosome Duplications Deduced from the Cloning and Mapping of the Five Receptor Subtype Genes in Pig
Genome Res., March 1, 2000; 10(3): 302 - 310.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. J. Larsen, M. Tang-Christensen, C. E. Stidsen, K. Madsen, M. S. Smith, and J. L. Cameron
Activation of Central Neuropeptide Y Y1 Receptors Potently Stimulates Food Intake in Male Rhesus Monkeys
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3781 - 3791.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Iyengar, D. L. Li, and R. M. A. Simmons
Characterization of Neuropeptide Y-Induced Feeding in Mice: Do Y1-Y6 Receptor Subtypes Mediate Feeding?
J. Pharmacol. Exp. Ther., May 1, 1999; 289(2): 1031 - 1040.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
L. Sun and R. J. Miller
Multiple Neuropeptide Y Receptors Regulate K+ and Ca2+ Channels in Acutely Isolated Neurons From the Rat Arcuate Nucleus
J Neurophysiol, March 1, 1999; 81(3): 1391 - 1403.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Meeran, D. O’Shea, C. M. B. Edwards, M. D. Turton, M. M. Heath, I. Gunn, S. Abusnana, M. Rossi, C. J. Small, A. P. Goldstone, et al.
Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7-36) Amide or Exendin-(9-39) Alters Body Weight in the Rat
Endocrinology, January 1, 1999; 140(1): 244 - 250.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
Y. Dumont, A. Fournier, and R. Quirion
Expression and Characterization of the Neuropeptide Y Y5 Receptor Subtype in the Rat Brain
J. Neurosci., August 1, 1998; 18(15): 5565 - 5574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Robidoux, L. Simoneau, S. St-Pierre, H. Ech-Chadli, and J. Lafond
Human syncytiotrophoblast NPY receptors are located on BBM and activate PLC-to-PKC axis
Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E502 - E509.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. J. Small, D. G. A. Morgan, K. Meeran, M. M. Heath, I. Gunn, C. M. B. Edwards, J. Gardiner, G. M. Taylor, J. D. Hurley, M. Rossi, et al.
Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release
PNAS, October 14, 1997; 94(21): 11686 - 11691.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society